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Effect of Aplidin in acute lymphoblastic leukaemia cells

The cytotoxic effect of Aplidin was investigated on fresh leukaemia cells derived from children with B-cell-precursor (BCP) acute lymphoblastic leukaemia (ALL) by using stromal-layer culture system and on four cell lines, ALL-PO, Reh, ALL/MIK and TOM-1, derived from patients with ALL with different molecular genetic abnormalities. In ALL cell lines Aplidin was cytotoxic at nanomolar concentrations. In the ALL cell lines the drug-induced cell death was clearly related to the induction of apopt...

Vorinostat (SAHA) May Exert Its Antidepressant-Like Effects Through the Modulation of Oxidative Stress Pathways

Suberoylanilide hydroxamic acid (SAHA/Vorinostat), a potent inhibitor of histone deacetylases (HDACs), is known to possess antidepressant properties. However, the exact mechanisms underlying this activity are unknown. In this study, we evaluated the effect of SAHA on the expression of GluN2A, GluN2B (NMDA receptor subunits), (p-)AMPK, and ΔFos proteins which are an integral part of the signal transduction pathways in the brain and also involved in the pathophysiology of depression as well as ...

Upregulation of the mGlu5 receptor and COX-2 protein in the mouse brain after imipramine and NS398, searching for mechanisms of regulation

Imipramine belongs to a group of tricyclic antidepressants (TCAs). It has been also documented that its antidepressant activity connects with the modulation of cytosolic phospholipase A2 (cPLA2) and arachidonic acid (AA) turnover. Through this mechanism, imipramine can indirectly modify glutamate (Glu) transmission. Additionally, it has been shown that chronic treatment with imipramine results in the upregulation of the metabotropic glutamate receptor subtype 5 (mGlu5 receptor) in the hippoca...

Antidepressant-like Effects of Combined Fluoxetine and Zinc Treatment in Mice Exposed to Chronic Restraint Stress Are Related to Modulation of Histone Deacetylase

Chronic stress is the key factor contributing to the development of depressive symptoms. Chronic restraint stress (CRS) is well validated and is one of the most commonly used models to induce depressive-like behavior in rodents. The present study aimed to evaluate whether fluox-etine (FLU 5 mg/kg) and zinc (Zn 10mg/kg) given simultaneously induce a more pronounced antidepressant-like effect in the CRS model than both those compounds given alone. Behavioral assessment was performed using the t...

Zinc Deficiency Blunts the Effectiveness of Antidepressants in the Olfactory Bulbectomy Model of Depression in Rats

Currently used antidepressants do not always provide the desired results, and many patients suffer from treatment-resistant depression. Clinical studies suggest that zinc deficiency (ZnD) may be an important risk factor for depression and might blunt the effect of antidepressants. This study aimed to examine whether ZnD might blunt the effectiveness of antidepressants in the olfactory bulbectomy model (OB) of depression in rats. For this purpose, rats were subjected to the OB model, fed a zin...

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Autore
  • GRASSI, GUIDO867
  • LUCCHINI, MARCO TOLIMAN786
  • CALVI, MARTA753
  • MORONI, LUIGI736
  • FIORENDI, SARA705
  • GOTTI, CLAUDIO671
  • CAVALETTI, GUIDO ANGELO648
  • CITERIO, GIUSEPPE645
  • SCOVAZZI, TULLIO609
  • MARTINELLI, MAURIZIO605
Keyword
  • Humans4662
  • Female2695
  • Male2362
  • Middle Aged1782
  • Adult1664
  • Aged1378
  • Italy1230
  • Animals963
  • Nuclear and High Energy Physics842
  • COVID-19715
Rivista
  • JOURNAL OF HIGH ENERGY PHYSICS939
  • PHYSICAL REVIEW LETTERS746
  • JOURNAL OF HYPERTENSION660
  • PHYSICS LETTERS. SECTION B552
  • PHYSICAL REVIEW D, PARTICLES, FIELDS, GRAVITATION, AND COSMOLOGY431
  • THE EUROPEAN PHYSICAL JOURNAL. C, PARTICLES AND FIELDS389
  • PLOS ONE373
  • MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY332
  • NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT316
  • SCIENTIFIC REPORTS301
Editore
  • Università degli Studi di Milano-Bicocca2565
  • Springer2395
  • Elsevier2111
  • Giuffrè1514
  • American Physical Society1460
  • Franco Angeli1385
  • Elsevier B.V.1362
  • Oxford University Press1362
  • Elsevier Ltd1306
  • Springer Verlag1246
Lingua
  • eng74941
  • ita33902
  • fre809
  • spa497
  • ger205
  • por132
  • ara39
  • chi24
  • enm19
  • jpn18
Settore disciplinare
  • M-PED/01 - PEDAGOGIA GENERALE E SOCIALE2854
  • INF/01 - INFORMATICA2193
  • SPS/07 - SOCIOLOGIA GENERALE1550
  • FIS/01 - FISICA SPERIMENTALE1435
  • SPS/08 - SOCIOLOGIA DEI PROCESSI CULTURALI E COMUNICATIVI1197
  • FIS/03 - FISICA DELLA MATERIA1141
  • M-PED/03 - DIDATTICA E PEDAGOGIA SPECIALE1077
  • M-DEA/01 - DISCIPLINE DEMOETNOANTROPOLOGICHE1048
  • SECS-S/01 - STATISTICA973
  • MAT/05 - ANALISI MATEMATICA927
Tipologia
  • 01 - Articolo su rivista66270
  • 02 - Intervento a convegno17666
  • 03 - Contributo in libro16444
  • 04 - Monografia2626
  • 07 - Tesi di dottorato Bicocca post 20092432
  • 99 - Altro2184
  • 05 - Curatele1725
  • 06 - Brevetti268
  • 03b - Traduzione in libro139
  • 09 - Tesi di dottorato129
  • 04c - Traduzione di libro128
  • 01b - Traduzione su rivista66
  • 04b - Edizione critica - fonti inedite - commento scientifico49
  • 08 - Tesi di specializzazione17
Accesso al fulltext
  • no fulltext82509
  • open13523
  • reserved12763
  • partially open1011
  • embargoed315
  • mixed22
Progetto
  • DIP-ECC-DISAT-2018232
  • SWAB71
  • NEMO28
  • SEARCH IV21
  • ISOTIS17
  • BALANCE15
  • Slow2Fast15
  • LEARN14
  • BiomarkARIA13
  • CHALLENGE12