Background: The available self-report questionnaire for the quality of life in patients with primary biliary cirrhosis (PBC-40) is currently validated only in the British population but it lacks an evaluation of its dimensionality. Aims: To validate the Italian and Japanese versions of PBC-40 and to assess the dimensionality of the original structure of PBC-40 by a confirmatory factor analysis. PBC-40 was translated to Italian and Japanese using the forward-backward method and then reviewed in focus groups in the framework of a large multicentric study. Methods: A sample of 290 patients with PBC (125 Italian and 165 Japanese) was administered two questionnaires previously validated for PBC-specific (PBC-40) and general quality of life (SF-36). Results: The confirmatory model failed to fit adequately the original hypothesized structure. A principal component analysis led to a seven-factor structure, with exclusion of 13 items characterized by lower load; PBC-27 questionnaire was the final instrument. The validity of the PBC-27 was supported by its strong correlation with the SF-36 scores. Conclusion: We here propose an alternative structure of the quality of life questionnaire for PBC, namely PBC-27, which appears to be effective in detecting the impact of PBC on quality of life in Italian and Japanese patients. © 2010 Editrice Gastroenterologica Italiana S.r.l.
Montali, L., Tanaka, A., Riva, P., Takahashi, H., Cocchi, C., Ueno, Y., et al. (2010). A short version of a HRQol questionnaire for Italian and Japanese patients with PBC. DIGESTIVE AND LIVER DISEASE, 42(10), 718-723 [10.1016/j.dld.2010.01.004].
|Citazione:||Montali, L., Tanaka, A., Riva, P., Takahashi, H., Cocchi, C., Ueno, Y., et al. (2010). A short version of a HRQol questionnaire for Italian and Japanese patients with PBC. DIGESTIVE AND LIVER DISEASE, 42(10), 718-723 [10.1016/j.dld.2010.01.004].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Titolo:||A short version of a HRQol questionnaire for Italian and Japanese patients with PBC|
|Autori:||Montali, L; Tanaka, A; Riva, P; Takahashi, H; Cocchi, C; Ueno, Y; Miglioretti, M; Takikawa, H; Vecchio, LP; Frigerio, A; Bianchi, I; Jorgensen, R; Lindor, KD; Podda, M; Invernizzi, P|
|Data di pubblicazione:||2010|
|Rivista:||DIGESTIVE AND LIVER DISEASE|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.dld.2010.01.004|
|Appare nelle tipologie:||01 - Articolo su rivista|