Background: The available self-report questionnaire for the quality of life in patients with primary biliary cirrhosis (PBC-40) is currently validated only in the British population but it lacks an evaluation of its dimensionality. Aims: To validate the Italian and Japanese versions of PBC-40 and to assess the dimensionality of the original structure of PBC-40 by a confirmatory factor analysis. PBC-40 was translated to Italian and Japanese using the forward-backward method and then reviewed in focus groups in the framework of a large multicentric study. Methods: A sample of 290 patients with PBC (125 Italian and 165 Japanese) was administered two questionnaires previously validated for PBC-specific (PBC-40) and general quality of life (SF-36). Results: The confirmatory model failed to fit adequately the original hypothesized structure. A principal component analysis led to a seven-factor structure, with exclusion of 13 items characterized by lower load; PBC-27 questionnaire was the final instrument. The validity of the PBC-27 was supported by its strong correlation with the SF-36 scores. Conclusion: We here propose an alternative structure of the quality of life questionnaire for PBC, namely PBC-27, which appears to be effective in detecting the impact of PBC on quality of life in Italian and Japanese patients. © 2010 Editrice Gastroenterologica Italiana S.r.l.

Montali, L., Tanaka, A., Riva, P., Takahashi, H., Cocchi, C., Ueno, Y., et al. (2010). A short version of a HRQol questionnaire for Italian and Japanese patients with PBC. DIGESTIVE AND LIVER DISEASE, 42(10), 718-723 [10.1016/j.dld.2010.01.004].

A short version of a HRQol questionnaire for Italian and Japanese patients with PBC

MONTALI, LORENZO;RIVA, PAOLO;MIGLIORETTI, MASSIMO;VECCHIO, LUCA PIERO;FRIGERIO, ALESSANDRA;INVERNIZZI, PIETRO
2010

Abstract

Background: The available self-report questionnaire for the quality of life in patients with primary biliary cirrhosis (PBC-40) is currently validated only in the British population but it lacks an evaluation of its dimensionality. Aims: To validate the Italian and Japanese versions of PBC-40 and to assess the dimensionality of the original structure of PBC-40 by a confirmatory factor analysis. PBC-40 was translated to Italian and Japanese using the forward-backward method and then reviewed in focus groups in the framework of a large multicentric study. Methods: A sample of 290 patients with PBC (125 Italian and 165 Japanese) was administered two questionnaires previously validated for PBC-specific (PBC-40) and general quality of life (SF-36). Results: The confirmatory model failed to fit adequately the original hypothesized structure. A principal component analysis led to a seven-factor structure, with exclusion of 13 items characterized by lower load; PBC-27 questionnaire was the final instrument. The validity of the PBC-27 was supported by its strong correlation with the SF-36 scores. Conclusion: We here propose an alternative structure of the quality of life questionnaire for PBC, namely PBC-27, which appears to be effective in detecting the impact of PBC on quality of life in Italian and Japanese patients. © 2010 Editrice Gastroenterologica Italiana S.r.l.
Articolo in rivista - Articolo scientifico
Factor structure, PBC-40, Principal component analysis, Quality of life
English
Montali, L., Tanaka, A., Riva, P., Takahashi, H., Cocchi, C., Ueno, Y., et al. (2010). A short version of a HRQol questionnaire for Italian and Japanese patients with PBC. DIGESTIVE AND LIVER DISEASE, 42(10), 718-723 [10.1016/j.dld.2010.01.004].
Montali, L; Tanaka, A; Riva, P; Takahashi, H; Cocchi, C; Ueno, Y; Miglioretti, M; Takikawa, H; Vecchio, L; Frigerio, A; Bianchi, I; Jorgensen, R; Lindor, K; Podda, M; Invernizzi, P
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/8196
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