Background & aims: Several symptoms impair the quality of life (QoL) of patients with primary biliary cholangitis (PBC). They are reported to vary significantly in different countries. Aim of our study was to explore whether there is a geographical clustering that accounts for symptoms in PBC. Methods: Data was analysed from four cohorts of PBC patients from the UK, Spain, Japan and Italy using the PBC-27 scale. Results: Overall, 569 patients from four cohorts were identified, including 515 females (90.5%) with a mean age of 61 years. The analysis provided evidence for strict factorial invariance of the scale, a robust indicator of its validity for cross-cultural research. The mean of the fatigue domain of British patients was significantly greater than that of the Japanese (p ​< ​0.05), Italian (p ​< ​0.05), and Spanish patients (p ​< ​0.001). The mean of the cognitive domain after 54 years of age, was significantly greater in the British patients than in the Japanese (p ​< ​0.05) and Spanish patients (p ​< ​0.01). However, after 69 years of age, there were not significant differences between countries. The mean of the emotion domain after 54 years of age, was greater in the British that in the Spanish (p ​< ​0.01) and Italian patients (p ​< ​0.01). Conclusions: Differences in the four countries concerning fatigue, cognitive and emotional dysfunction were found. The association of latitude and symptoms might provide new insights into the role of sun exposure, genetics and/or cultural component into disease phenotype in PBC.

Montali, L., Gragnano, A., Miglioretti, M., Frigerio, A., Vecchio, L., Gerussi, A., et al. (2021). Quality of life in patients with primary biliary cholangitis: a cross-geographical comparison. JOURNAL OF TRANSLATIONAL AUTOIMMUNITY, 4 [10.1016/j.jtauto.2021.100081].

Quality of life in patients with primary biliary cholangitis: a cross-geographical comparison

Montali, Lorenzo;Gragnano, Andrea;Miglioretti, Massimo;Frigerio, Alessandra;Vecchio, Luca;Gerussi, Alessio;Cristoferi, Laura;Mancuso, Clara;Lucà, Martina;Carbone, Marco;Invernizzi, Pietro
2021

Abstract

Background & aims: Several symptoms impair the quality of life (QoL) of patients with primary biliary cholangitis (PBC). They are reported to vary significantly in different countries. Aim of our study was to explore whether there is a geographical clustering that accounts for symptoms in PBC. Methods: Data was analysed from four cohorts of PBC patients from the UK, Spain, Japan and Italy using the PBC-27 scale. Results: Overall, 569 patients from four cohorts were identified, including 515 females (90.5%) with a mean age of 61 years. The analysis provided evidence for strict factorial invariance of the scale, a robust indicator of its validity for cross-cultural research. The mean of the fatigue domain of British patients was significantly greater than that of the Japanese (p ​< ​0.05), Italian (p ​< ​0.05), and Spanish patients (p ​< ​0.001). The mean of the cognitive domain after 54 years of age, was significantly greater in the British patients than in the Japanese (p ​< ​0.05) and Spanish patients (p ​< ​0.01). However, after 69 years of age, there were not significant differences between countries. The mean of the emotion domain after 54 years of age, was greater in the British that in the Spanish (p ​< ​0.01) and Italian patients (p ​< ​0.01). Conclusions: Differences in the four countries concerning fatigue, cognitive and emotional dysfunction were found. The association of latitude and symptoms might provide new insights into the role of sun exposure, genetics and/or cultural component into disease phenotype in PBC.
Articolo in rivista - Articolo scientifico
Autoimmunity; Cholestasis; Fatigue; Liver;
English
Gold Open Access• Green Open Access
Montali, L., Gragnano, A., Miglioretti, M., Frigerio, A., Vecchio, L., Gerussi, A., et al. (2021). Quality of life in patients with primary biliary cholangitis: a cross-geographical comparison. JOURNAL OF TRANSLATIONAL AUTOIMMUNITY, 4 [10.1016/j.jtauto.2021.100081].
File in questo prodotto:
File Dimensione Formato  
JTAUTO fatigue PBC jan21.pdf

accesso aperto

Descrizione: Main document
Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Dimensione 1.14 MB
Formato Adobe PDF
1.14 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/301150
Citazioni
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 2
Social impact