Aging and age-related neurodegenerations are among the main challenges in modern medicine. Parkinson’s disease (PD), associated with the misfolding of α-synuclein protein, affects about 10 million people worldwide. In recent years, the protective effects of several plant-derived bioactive compounds have been highlighted on a wide variety of diseases, such as neurodegenerative diseases. The valorization of the huge Italian flora biodiversity is one of the main goals of the National Biodiversity Future Centre (NBFC). To identify still unexplored bioactive molecules with potential neuroprotective and anti-aging properties, the extracts of 63 Italian endemic plants were screened on eukaryotic models of Parkinson’s disease expressing human α-synuclein. The selected 4 plants and their components are now under investigation to elucidate the underlying mechanisms that contribute to the prevention and inhibition of α-synuclein aggregation.
Lambiase, A., Moukham, H., Spandri, G., Pagliari, S., Campone, L., Guzzo, F., et al. (2024). Neuroprotective and anti-aging effects of plant extracts on eukaryotic models of Parkinson’s disease. Intervento presentato a: PhD meeting 2004, Milano, Italia.
Neuroprotective and anti-aging effects of plant extracts on eukaryotic models of Parkinson’s disease
Lambiase A.;Moukham H.;Spandri G.;Pagliari S.;Campone L.;Tripodi F.;Coccetti P.
2024
Abstract
Aging and age-related neurodegenerations are among the main challenges in modern medicine. Parkinson’s disease (PD), associated with the misfolding of α-synuclein protein, affects about 10 million people worldwide. In recent years, the protective effects of several plant-derived bioactive compounds have been highlighted on a wide variety of diseases, such as neurodegenerative diseases. The valorization of the huge Italian flora biodiversity is one of the main goals of the National Biodiversity Future Centre (NBFC). To identify still unexplored bioactive molecules with potential neuroprotective and anti-aging properties, the extracts of 63 Italian endemic plants were screened on eukaryotic models of Parkinson’s disease expressing human α-synuclein. The selected 4 plants and their components are now under investigation to elucidate the underlying mechanisms that contribute to the prevention and inhibition of α-synuclein aggregation.
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