The gene expression programs regulated by the Myc transcription factor were evaluated by integrated genome-wide profiling of Myc binding sites, chromatin marks and RNA expression in several biological models. Our results indicate that Myc directly drives selective transcriptional regulation, which in certain physiological conditions may indirectly lead to RNA amplification. Here, we illustrate in detail the experimental design concerning the high-throughput sequencing data associated with our study (Sabò et al., Nature. (2014) 511:488-492) and the R scripts used for their computational analysis.
Pelizzola, M., Morelli, M., Sabò, A., Kress, T., de Pretis, S., Amati, B. (2015). Selective transcriptional regulation by Myc: Experimental design and computational analysis of high-throughput sequencing data. DATA IN BRIEF, 3, 40-46 [10.1016/j.dib.2015.02.003].
Selective transcriptional regulation by Myc: Experimental design and computational analysis of high-throughput sequencing data
Pelizzola, M
;
2015
Abstract
The gene expression programs regulated by the Myc transcription factor were evaluated by integrated genome-wide profiling of Myc binding sites, chromatin marks and RNA expression in several biological models. Our results indicate that Myc directly drives selective transcriptional regulation, which in certain physiological conditions may indirectly lead to RNA amplification. Here, we illustrate in detail the experimental design concerning the high-throughput sequencing data associated with our study (Sabò et al., Nature. (2014) 511:488-492) and the R scripts used for their computational analysis.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Pelizzola-2015-Data in Brief-VoR.pdf
accesso aperto
Descrizione: Data article
Tipologia di allegato:
Publisher’s Version (Version of Record, VoR)
Licenza:
Creative Commons
Dimensione
156.13 kB
Formato
Adobe PDF
|
156.13 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
