Thyroid fine-needle aspiration (FNA) is a commonly used diagnostic cytological procedure in pediatric patients for the evaluation of thyroid nodules, triaging them for the detection of thyroid cancer. In recent years, greater attention has been paid to thyroid FNA in this setting, including the use of updated ultrasound score algorithms to improve accuracy and yield, especially considering the theoretically higher risk of malignancy of these lesions compared with the adult population, as well as to minimize patient discomfort. Moreover, molecular genetic testing for thyroid disease is an expanding field of research that could aid in distinguishing benign from cancerous nodules and assist in determining their clinical management. Finally, artificial intelligence tools can help in this task by performing a comprehensive analysis of all the obtained data. These advancements have led to greater reliance on FNA as a first-line diagnostic tool for pediatric thyroid disease. This review article provides an overview of these recent developments and their impact on the diagnosis and management of thyroid nodules in children.

Seminati, D., Ceola, S., Pincelli, A., Leni, D., Gatti, A., Garancini, M., et al. (2023). The Complex Cyto-Molecular Landscape of Thyroid Nodules in Pediatrics. CANCERS, 15(7) [10.3390/cancers15072039].

The Complex Cyto-Molecular Landscape of Thyroid Nodules in Pediatrics

Seminati, Davide;Ceola, Stefano;Pincelli, Angela Ida;Garancini, Mattia;L'Imperio, Vincenzo;Cattoni, Alessandro;Pagni, Fabio
2023

Abstract

Thyroid fine-needle aspiration (FNA) is a commonly used diagnostic cytological procedure in pediatric patients for the evaluation of thyroid nodules, triaging them for the detection of thyroid cancer. In recent years, greater attention has been paid to thyroid FNA in this setting, including the use of updated ultrasound score algorithms to improve accuracy and yield, especially considering the theoretically higher risk of malignancy of these lesions compared with the adult population, as well as to minimize patient discomfort. Moreover, molecular genetic testing for thyroid disease is an expanding field of research that could aid in distinguishing benign from cancerous nodules and assist in determining their clinical management. Finally, artificial intelligence tools can help in this task by performing a comprehensive analysis of all the obtained data. These advancements have led to greater reliance on FNA as a first-line diagnostic tool for pediatric thyroid disease. This review article provides an overview of these recent developments and their impact on the diagnosis and management of thyroid nodules in children.
Articolo in rivista - Review Essay
fine-needle aspiration; molecular pathology; pediatrics; thyroid nodule; ultrasound;
English
29-mar-2023
2023
15
7
2039
none
Seminati, D., Ceola, S., Pincelli, A., Leni, D., Gatti, A., Garancini, M., et al. (2023). The Complex Cyto-Molecular Landscape of Thyroid Nodules in Pediatrics. CANCERS, 15(7) [10.3390/cancers15072039].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/413515
Citazioni
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
Social impact