Aims: To describe the proportion of patients with syncope among those affected by hypertrophic cardiomyopathy (HCM) and the relevance of syncope as risk factor for sudden cardiac death and life-threatening arrhythmic events. Method and results: Systematic review of original articles that assessed syncope in HCM patients. Literature search of PubMed including all English publications from 1973 to 2021.We found 57 articles for a total of 21.791 patients; of these, 14 studies reported on arrhythmic events in the follow-up. Syncope was reported in 15.8% (3.452 of 21.791) patients. It was considered unexplained in 91% of cases. Life-threatening arrhythmic events occurred in 3.6% of non-syncopal patients and in 7.7% of syncopal patients during a mean follow-up of 5.6 years. A relative risk of 1.99 (95%CI 1.39 to 2.86) was estimated for syncope patients by the random effect model using Haldane continuity correction for 0 events. Conclusions: In the current practice, the cause of syncope remained unexplained in most patients affected by HCM. The management of patients seems mainly driven by risk stratification rather than identification of the aetiology of syncope. There is a need of precise instructions how to apply the recommendations of current guidelines to this disease, which tests are indicated and how to interpret their findings. The protocol was registered in Prospero (ID: 275963).

Mascia, G., Crotti, L., Groppelli, A., Canepa, M., Merlo, A., Benenati, S., et al. (2022). Syncope in hypertrophic cardiomyopathy (part I): An updated systematic review and meta-analysis. INTERNATIONAL JOURNAL OF CARDIOLOGY, 357(15 June 2022), 88-94 [10.1016/j.ijcard.2022.03.028].

Syncope in hypertrophic cardiomyopathy (part I): An updated systematic review and meta-analysis

Crotti L.;Soranna D.;Zambon A.;Parati G.;
2022

Abstract

Aims: To describe the proportion of patients with syncope among those affected by hypertrophic cardiomyopathy (HCM) and the relevance of syncope as risk factor for sudden cardiac death and life-threatening arrhythmic events. Method and results: Systematic review of original articles that assessed syncope in HCM patients. Literature search of PubMed including all English publications from 1973 to 2021.We found 57 articles for a total of 21.791 patients; of these, 14 studies reported on arrhythmic events in the follow-up. Syncope was reported in 15.8% (3.452 of 21.791) patients. It was considered unexplained in 91% of cases. Life-threatening arrhythmic events occurred in 3.6% of non-syncopal patients and in 7.7% of syncopal patients during a mean follow-up of 5.6 years. A relative risk of 1.99 (95%CI 1.39 to 2.86) was estimated for syncope patients by the random effect model using Haldane continuity correction for 0 events. Conclusions: In the current practice, the cause of syncope remained unexplained in most patients affected by HCM. The management of patients seems mainly driven by risk stratification rather than identification of the aetiology of syncope. There is a need of precise instructions how to apply the recommendations of current guidelines to this disease, which tests are indicated and how to interpret their findings. The protocol was registered in Prospero (ID: 275963).
Articolo in rivista - Articolo scientifico
Diagnostic tests; Hypertrophic cardiomyopathy; Lifethreatening arrhythmias; Sudden death; Syncope;
English
15-mar-2022
2022
357
15 June 2022
88
94
reserved
Mascia, G., Crotti, L., Groppelli, A., Canepa, M., Merlo, A., Benenati, S., et al. (2022). Syncope in hypertrophic cardiomyopathy (part I): An updated systematic review and meta-analysis. INTERNATIONAL JOURNAL OF CARDIOLOGY, 357(15 June 2022), 88-94 [10.1016/j.ijcard.2022.03.028].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/392931
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