Many large national and transnational studies have been dedicated to the analysis of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) genome, most of which focused on missense and nonsense mutations. However, approximately 30 per cent of the SARS-CoV-2 variants are synonymous, therefore changing the target codon without affecting the corresponding protein sequence. By performing a large-scale analysis of sequencing data generated from almost 400,000 SARS-CoV-2 samples, we show that silent mutations increasing the similarity of viral codons to the human ones tend to fixate in the viral genome overtime. This indicates that SARS-CoV-2 codon usage is adapting to the human host, likely improving its effectiveness in using the human aminoacyl-tRNA set through the accumulation of deceitfully neutral silent mutations. One-Sentence Summary. Synonymous SARS-CoV-2 mutations related to the activity of different mutational processes may positively impact viral evolution by increasing its adaptation to the human codon usage.
Ramazzotti, D., Angaroni, F., Maspero, D., Mauri, M., D’Aliberti, D., Fontana, D., et al. (2022). Large-Scale Analysis of SARS-CoV-2 Synonymous Mutations Reveals the Adaptation to the Human Codon Usage During the Virus Evolution. VIRUS EVOLUTION, 8(1) [10.1093/ve/veac026].
Citazione: | Ramazzotti, D., Angaroni, F., Maspero, D., Mauri, M., D’Aliberti, D., Fontana, D., et al. (2022). Large-Scale Analysis of SARS-CoV-2 Synonymous Mutations Reveals the Adaptation to the Human Codon Usage During the Virus Evolution. VIRUS EVOLUTION, 8(1) [10.1093/ve/veac026]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | Large-Scale Analysis of SARS-CoV-2 Synonymous Mutations Reveals the Adaptation to the Human Codon Usage During the Virus Evolution | |
Autori: | Ramazzotti, D; Angaroni, F; Maspero, D; Mauri, M; D’Aliberti, D; Fontana, D; Antoniotti, M; Elli, E; Graudenzi, A; Piazza, R | |
Autori: | ELLI, ELENA MARIA (Co-ultimo) GRAUDENZI, ALEX (Co-ultimo) PIAZZA, ROCCO GIOVANNI (Co-ultimo) (Corresponding) | |
Data di pubblicazione: | 2022 | |
Lingua: | English | |
Rivista: | VIRUS EVOLUTION | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1093/ve/veac026 | |
Appare nelle tipologie: | 01 - Articolo su rivista |