Random Boolean networks provide a way to give a precise meaning to the notion that living beings are in a critical state. Some phenomena which are observed in real biological systems (distribution of "avalanches" in gene knock-out experiments) call be modeled using random Boolean networks, and the results can be analytically proven to depend upon the Derrida parameter, which also determines whether the network is critical. By comparing observed and simulated data one can then draw inferences about the criticality of biological cells, although with some care because of the limited number of experimental observations. The relationship between the criticality of a single network and that of a set of interacting networks, which simulate a tissue or a bacterial colony, is also analyzed by computer simulations.

Serra, R., Villani, M., Damiani, C., Graudenzi, A., Ingrami, P., Colacci, A. (2009). Investigating Cell Criticality. In Proceedings of the International Conference Castel Ivano, Italy, 18 – 20 October 2007. Processes of Emergence of Systems and Systemic Properties Towards a General Theory of Emergence (pp.649-657). Singapore : World Scientific Publ Co PTE LTD [10.1142/9789812793478_0041].

Investigating Cell Criticality

Damiani, C;Graudenzi, A;
2009

Abstract

Random Boolean networks provide a way to give a precise meaning to the notion that living beings are in a critical state. Some phenomena which are observed in real biological systems (distribution of "avalanches" in gene knock-out experiments) call be modeled using random Boolean networks, and the results can be analytically proven to depend upon the Derrida parameter, which also determines whether the network is critical. By comparing observed and simulated data one can then draw inferences about the criticality of biological cells, although with some care because of the limited number of experimental observations. The relationship between the criticality of a single network and that of a set of interacting networks, which simulate a tissue or a bacterial colony, is also analyzed by computer simulations.
No
slide + paper
Random Boolean networks; cell criticality; interacting networks
English
4th National Conference of the Italian-Systems-Society
978-981-279-346-1
Serra, R., Villani, M., Damiani, C., Graudenzi, A., Ingrami, P., Colacci, A. (2009). Investigating Cell Criticality. In Proceedings of the International Conference Castel Ivano, Italy, 18 – 20 October 2007. Processes of Emergence of Systems and Systemic Properties Towards a General Theory of Emergence (pp.649-657). Singapore : World Scientific Publ Co PTE LTD [10.1142/9789812793478_0041].
Serra, R; Villani, M; Damiani, C; Graudenzi, A; Ingrami, P; Colacci, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/192024
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