Rationale: Granulomatosis with polyangiitis (GPA) is an antineutrophil cytoplasmatic antibodies (ANCA)-associated vasculitis affecting small- and medium-sized blood vessels, mostly involving lung and kidney. Patient concerns: We report the case of a 33-year-old man that presented with acute respiratory distress syndrome caused by alveolar hemorrhage. Diagnoses: Aggressive GPA presenting with diffuse alveolar hemorrhage and multiorgan involvement. Inteventions: Immunosuppressive therapy, plasma exchange, extracorporeal membrane oxygenation (ECMO). Outcomes: Relapse occurred very early, despite immunosuppressive treatment, with a rare involvement of genital system (epididymitis) and rapidly progressive glomerulonephritis difficult to treat. Lessons: GPA is a challenging, multifaceted disease that can require aggressive supportive therapy and is associated with a high rate of relapse that may present with uncommon site of involvement
Citazione: | Vanoli, J., Riva, M., Vergnano, B., D'Andrea, G., L'Imperio, V., Pozzi, M., et al. (2017). Granulomatosis with polyangiitis presenting with diffuse alveolar hemorrhage requiring extracorporeal membrane oxygenation with rapid multiorgan relapse: A case report. MEDICINE, 96(13). |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | No |
Titolo: | Granulomatosis with polyangiitis presenting with diffuse alveolar hemorrhage requiring extracorporeal membrane oxygenation with rapid multiorgan relapse: A case report |
Autori: | Vanoli, J; Riva, M; Vergnano, B; D'Andrea, G; L'Imperio, V; Pozzi, M; Grassi, G |
Autori: | |
Data di pubblicazione: | 2017 |
Lingua: | English |
Rivista: | MEDICINE |
Digital Object Identifier (DOI): | 10.1097/MD.0000000000006024 |
Appare nelle tipologie: | 01 - Articolo su rivista |