Purpose: To investigate the relationship between peak (EAdipeak) and area under the curve (EAdiAUC) of diaphragm electrical activity, and to evaluate the validity of their ratio (P/I index) as a measure of the imbalance between drive and sustainability of effort demand at different support levels. Materials: Prospective physiological study on 18 ready-to-wean patients ventilated with neurally adjusted ventilatory assist (NAVA) undergoing 2 levels of NAVA (NAVA100% and NAVA50%) followed by a weaning trial with continuous positive airway pressure, according to which patients were classified as success or failure. Tidal volume (VT), respiratory rate, EAdipeak, EAdiAUC, rapid shallow breathing index (respiratory rate/VT), neuroventilatory index (VT/EAdipeak), and P/I index were obtained at the end of each step. Results: The slopes of regression line between EAdipeak and EAdiAUC (a mathematical equivalent of P/I index) and P/I index were significantly higher in failures. At variance with other variables, P/I index did not vary with level of support. P/I index was inversely correlated with inspiratory time at all support levels. Conclusions: The relationship between EAdipeak and EAdiAUC and the P/I index may give important information on the balance between respiratory drive and inspiratory demand sustainability.

Muttini, S., Villani, P., Trimarco, R., Bellani, G., Grasselli, G., & Patroniti, N. (2015). Relation between peak and integral of the diaphragm electromyographic activity at different levels of support during weaning from mechanical ventilation: A physiologic study. JOURNAL OF CRITICAL CARE, 30(1), 7-12 [10.1016/j.jcrc.2014.08.013].

Relation between peak and integral of the diaphragm electromyographic activity at different levels of support during weaning from mechanical ventilation: A physiologic study

TRIMARCO, ROBERTA;BELLANI, GIACOMO;GRASSELLI, GIACOMO
Penultimo
;
PATRONITI, NICOLO' ANTONINO
Ultimo
2015

Abstract

Purpose: To investigate the relationship between peak (EAdipeak) and area under the curve (EAdiAUC) of diaphragm electrical activity, and to evaluate the validity of their ratio (P/I index) as a measure of the imbalance between drive and sustainability of effort demand at different support levels. Materials: Prospective physiological study on 18 ready-to-wean patients ventilated with neurally adjusted ventilatory assist (NAVA) undergoing 2 levels of NAVA (NAVA100% and NAVA50%) followed by a weaning trial with continuous positive airway pressure, according to which patients were classified as success or failure. Tidal volume (VT), respiratory rate, EAdipeak, EAdiAUC, rapid shallow breathing index (respiratory rate/VT), neuroventilatory index (VT/EAdipeak), and P/I index were obtained at the end of each step. Results: The slopes of regression line between EAdipeak and EAdiAUC (a mathematical equivalent of P/I index) and P/I index were significantly higher in failures. At variance with other variables, P/I index did not vary with level of support. P/I index was inversely correlated with inspiratory time at all support levels. Conclusions: The relationship between EAdipeak and EAdiAUC and the P/I index may give important information on the balance between respiratory drive and inspiratory demand sustainability.
Articolo in rivista - Articolo scientifico
Diaphragmatic electrical activity; Neutrally adjusted ventilator assist; Ventilator weaning; Aged; Area Under Curve; Diaphragm; Electromyography; Female; Humans; Male; Middle Aged; Prospective Studies; Respiration, Artificial; Respiratory Insufficiency; Respiratory Rate; Tidal Volume; Ventilator Weaning
English
7
12
6
Muttini, S., Villani, P., Trimarco, R., Bellani, G., Grasselli, G., & Patroniti, N. (2015). Relation between peak and integral of the diaphragm electromyographic activity at different levels of support during weaning from mechanical ventilation: A physiologic study. JOURNAL OF CRITICAL CARE, 30(1), 7-12 [10.1016/j.jcrc.2014.08.013].
Muttini, S; Villani, P; Trimarco, R; Bellani, G; Grasselli, G; Patroniti, N
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/98735
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