Sex cord stromal tumors (SCST) are rare cancers of the ovarian area in adults. They constitute a heterogeneous group of tumors that develop from the sex cords and the ovarian stroma. These tumors are detected typically at an early stage, and they may recur as late as 30 years after the initial treatment. Because 70% of the patients present with stage I tumors, surgery represents the most important therapeutic arm. There are no data to support any kind of postoperative adjuvant treatment for patients with stage IA or IB SCSTs, given the indolent nature of these neoplasms and the overall good prognosis. The long natural history of the disease may lead to repeated surgical procedure should a relapse occurs. Platinum-based chemotherapy is currently used for patients with advanced stage SCSTs or recurrent disease, with an overall response rate of 63% to 80%. The indolent nature of SCSTs with the tendency for late recurrence requires long-term follow-up

Ray Coquard, I., Brown, J., Harter, P., Provencher, D., Fong, P., Maenpaa, J., et al. (2014). Gynecologic Cancer InterGroup (GCIG) consensus review for ovarian sex cord stromal tumors. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 24(9 supp 3), S42-S47 [10.1097/IGC.0000000000000249].

Gynecologic Cancer InterGroup (GCIG) consensus review for ovarian sex cord stromal tumors

COLOMBO, NICOLETTA
Ultimo
2014

Abstract

Sex cord stromal tumors (SCST) are rare cancers of the ovarian area in adults. They constitute a heterogeneous group of tumors that develop from the sex cords and the ovarian stroma. These tumors are detected typically at an early stage, and they may recur as late as 30 years after the initial treatment. Because 70% of the patients present with stage I tumors, surgery represents the most important therapeutic arm. There are no data to support any kind of postoperative adjuvant treatment for patients with stage IA or IB SCSTs, given the indolent nature of these neoplasms and the overall good prognosis. The long natural history of the disease may lead to repeated surgical procedure should a relapse occurs. Platinum-based chemotherapy is currently used for patients with advanced stage SCSTs or recurrent disease, with an overall response rate of 63% to 80%. The indolent nature of SCSTs with the tendency for late recurrence requires long-term follow-up
Articolo in rivista - Articolo scientifico
sex cord stromal tumors, ovarian tumors, gynecologic cancer intergroup post-operative adjuvant treatment
English
2014
24
9 supp 3
S42
S47
none
Ray Coquard, I., Brown, J., Harter, P., Provencher, D., Fong, P., Maenpaa, J., et al. (2014). Gynecologic Cancer InterGroup (GCIG) consensus review for ovarian sex cord stromal tumors. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 24(9 supp 3), S42-S47 [10.1097/IGC.0000000000000249].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/97631
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