Both in clinical practice and in drug trials, combination treatment of hypertension plays a fundamental role. This article reviews the features that make combined therapy with two drugs valuable, i.e., additive antihypertensive efficacy, different mechanisms of action, and reciprocal side-effect minimization. Also examined are the advantages and disadvantages of a fixed combination, emphasizing that a major advantage is simplification of the treatment schedule. This is clinically relevant because complexity of treatment negatively affects patient compliance, which in hypertensive patients is poor, leading to poor long-term blood pressure control in the hypertensive fraction of the population.
Mancia, G., Failla, M., Grappiolo, A., & Giannattasio, C. (1998). Present and future role of combination treatment in hypertension. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 31 Suppl 2, S41-S44.
Citazione: | Mancia, G., Failla, M., Grappiolo, A., & Giannattasio, C. (1998). Present and future role of combination treatment in hypertension. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 31 Suppl 2, S41-S44. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | No |
Titolo: | Present and future role of combination treatment in hypertension |
Autori: | Mancia, G; Failla, M; Grappiolo, A; Giannattasio, C |
Autori: | MANCIA, GIUSEPPE (Primo) FAILLA, MONICA (Secondo) GIANNATTASIO, CRISTINA (Ultimo) |
Data di pubblicazione: | 1998 |
Lingua: | English |
Rivista: | JOURNAL OF CARDIOVASCULAR PHARMACOLOGY |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1097/00005344-199800002-00007 |
Appare nelle tipologie: | 01 - Articolo su rivista |