We describe the synthesis of sugar-fused beta-disubstituted gamma-butyrolactones, gamma-butyrolactams and a lipophilic beta-disubstituted GABA analogue as potential GABA receptor ligands, where the pharmacophore is engineered into the carbohydrate scaffold in the form of a C-fructoside. The products were characterized for receptor binding studies of GABAA receptors
Araujo, A., Nicotra, F., Costa, B., Giagnoni, G., Cipolla, L. (2008). Fructose-fused gamma-butyrolactones and lactams, synthesis and biological evaluation as GABA receptor ligands. CARBOHYDRATE RESEARCH, 343(10-11), 1840-1848 [10.1016/j.carres.2008.03.013].
Fructose-fused gamma-butyrolactones and lactams, synthesis and biological evaluation as GABA receptor ligands
NICOTRA, FRANCESCO;COSTA, BARBARA SIMONA;GIAGNONI, GABRIELLA;CIPOLLA, LAURA FRANCESCA
2008
Abstract
We describe the synthesis of sugar-fused beta-disubstituted gamma-butyrolactones, gamma-butyrolactams and a lipophilic beta-disubstituted GABA analogue as potential GABA receptor ligands, where the pharmacophore is engineered into the carbohydrate scaffold in the form of a C-fructoside. The products were characterized for receptor binding studies of GABAA receptors
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