Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus (EBV)-driven lymphoproliferative disease that usually arises in the context of reduced immunological surveillance. Based on histology, two forms of the disease are recognized, namely low-grade and high-grade LYG. Clinically, LYG universally involves the lungs and, frequently, also the skin, central nervous system, liver, and kidneys. Here, we present the case of a 55-year-old woman with a difficult-to-diagnose low-grade LYG with symptomatic lung involvement, who concomitantly was newly diagnosed with human immunodeficiency virus (HIV) infection. Rapid immune recovery achieved through antiretroviral therapy led to a complete and sustained clinical and radiological remission of LYG.

Kogan, M., Alviano, A., Catalano, M., Casiraghi, A., Ghilardi, G., Rindone, G., et al. (2025). Remission of low-grade lymphomatoid granulomatosis with extensive pulmonary involvement following immune restoration via antiretroviral therapy in a newly diagnosed HIV patient. AIDS RESEARCH AND THERAPY, 22(1) [10.1186/s12981-025-00717-9].

Remission of low-grade lymphomatoid granulomatosis with extensive pulmonary involvement following immune restoration via antiretroviral therapy in a newly diagnosed HIV patient

Kogan, Maria;Alviano, Antonio Maria;Catalano, Martina;Casiraghi, Alessandra;Ghilardi, Giulia;Rindone, Giovanni;Verga, Luisa;L'Imperio, Vincenzo;Passerini, Carlo Gambacorti;Bonfanti, Paolo;Lapadula, Giuseppe;Cocito, Federica;Soria, Alessandro
2025

Abstract

Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus (EBV)-driven lymphoproliferative disease that usually arises in the context of reduced immunological surveillance. Based on histology, two forms of the disease are recognized, namely low-grade and high-grade LYG. Clinically, LYG universally involves the lungs and, frequently, also the skin, central nervous system, liver, and kidneys. Here, we present the case of a 55-year-old woman with a difficult-to-diagnose low-grade LYG with symptomatic lung involvement, who concomitantly was newly diagnosed with human immunodeficiency virus (HIV) infection. Rapid immune recovery achieved through antiretroviral therapy led to a complete and sustained clinical and radiological remission of LYG.
Articolo in rivista - Articolo scientifico
Lymphomatoid granulomatosis, Immune recovery, HIV, Lung infiltrates, Low-grade histology
English
15-feb-2025
2025
22
1
19
open
Kogan, M., Alviano, A., Catalano, M., Casiraghi, A., Ghilardi, G., Rindone, G., et al. (2025). Remission of low-grade lymphomatoid granulomatosis with extensive pulmonary involvement following immune restoration via antiretroviral therapy in a newly diagnosed HIV patient. AIDS RESEARCH AND THERAPY, 22(1) [10.1186/s12981-025-00717-9].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/540768
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