There is no clear consensus regarding systemic treatment of early-stage ovarian cancer (OC). Clinical trials are challenging because of the relatively low incidence and good prognosis. Initial results of the International Collaborative Ovarian Neoplasm (ICON)1 trial demonstrated benefit in both overall survival (OS) and recurrence-free survival (RFS) with adjuvant chemotherapy. We report results of 10-year follow-up to establish whether benefits are maintained longer term and discuss how this and other available evidence from randomised trials can be used to guide treatment options regarding the need for, and choice of, adjuvant chemotherapy regimen.

Collinson, F., Qian, W., Fossati, R., Lissoni, A., Williams, C., Parmar, M., et al. (2014). Optimal treatment of early-stage ovarian cancer. ANNALS OF ONCOLOGY, 25(6), 1165-1171 [10.1093/annonc/mdu116].

Optimal treatment of early-stage ovarian cancer

LISSONI, ANDREA ALBERTO;COLOMBO, NICOLETTA;
2014

Abstract

There is no clear consensus regarding systemic treatment of early-stage ovarian cancer (OC). Clinical trials are challenging because of the relatively low incidence and good prognosis. Initial results of the International Collaborative Ovarian Neoplasm (ICON)1 trial demonstrated benefit in both overall survival (OS) and recurrence-free survival (RFS) with adjuvant chemotherapy. We report results of 10-year follow-up to establish whether benefits are maintained longer term and discuss how this and other available evidence from randomised trials can be used to guide treatment options regarding the need for, and choice of, adjuvant chemotherapy regimen.
Articolo in rivista - Articolo scientifico
early-stage ovarian cancer; ICON3; ICON1; adjuvant chemotherapy
English
2014
25
6
1165
1171
none
Collinson, F., Qian, W., Fossati, R., Lissoni, A., Williams, C., Parmar, M., et al. (2014). Optimal treatment of early-stage ovarian cancer. ANNALS OF ONCOLOGY, 25(6), 1165-1171 [10.1093/annonc/mdu116].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/53030
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