This article investigates the bioluminescence inhibition effects of the antimicrobials triclocarban, triclosan and its metabolite methyl triclosan, using the marine bacterium Vibrio fischeri as the test organism (Microtox©). The concentration response analysis was performed for the three individual substances and for a mixture in which the three compounds were mixed in a ratio of the IC50 of the individual components (equitoxic ratio). Toxicity values (the median inhibitory concentration value, in mgL-1) in the decreasing order of sensitivity were triclosan (0.73)>triclocarban (0.91)>methyl-triclosan (1.76). The comparison of the experimental data with those obtained by using Quantitative Structure-Activity Relationship (QSAR) equations indicated that triclosan and triclocarban act as polar narcotic compounds towards V. fischeri, whereas methyl-triclosan acts as a narcotic (baseline toxicity). The toxicity of the mixture was measured experimentally and predicted by two models (CA: concentration addition; IA: independent action). The results showed that the observed mixture toxicity (IC50=0.23mgL-1) had no significant differences from those predicted by both CA and IA models.

Villa, S., Vighi, M., Finizio, A. (2014). Experimental and predicted acute toxicity of antibacterial compounds and their mixtures using the luminescent bacterium Vibrio fischeri. CHEMOSPHERE, 108, 239-244 [10.1016/j.chemosphere.2014.01.046].

Experimental and predicted acute toxicity of antibacterial compounds and their mixtures using the luminescent bacterium Vibrio fischeri

VILLA, SARA;VIGHI, MARCO;FINIZIO, ANTONIO
2014

Abstract

This article investigates the bioluminescence inhibition effects of the antimicrobials triclocarban, triclosan and its metabolite methyl triclosan, using the marine bacterium Vibrio fischeri as the test organism (Microtox©). The concentration response analysis was performed for the three individual substances and for a mixture in which the three compounds were mixed in a ratio of the IC50 of the individual components (equitoxic ratio). Toxicity values (the median inhibitory concentration value, in mgL-1) in the decreasing order of sensitivity were triclosan (0.73)>triclocarban (0.91)>methyl-triclosan (1.76). The comparison of the experimental data with those obtained by using Quantitative Structure-Activity Relationship (QSAR) equations indicated that triclosan and triclocarban act as polar narcotic compounds towards V. fischeri, whereas methyl-triclosan acts as a narcotic (baseline toxicity). The toxicity of the mixture was measured experimentally and predicted by two models (CA: concentration addition; IA: independent action). The results showed that the observed mixture toxicity (IC50=0.23mgL-1) had no significant differences from those predicted by both CA and IA models.
Articolo in rivista - Articolo scientifico
Mixtures toxicity, Triclosan, Methyl-triclosan, Triclocarban, Microtox;
English
2014
108
239
244
none
Villa, S., Vighi, M., Finizio, A. (2014). Experimental and predicted acute toxicity of antibacterial compounds and their mixtures using the luminescent bacterium Vibrio fischeri. CHEMOSPHERE, 108, 239-244 [10.1016/j.chemosphere.2014.01.046].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/50435
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