Yeasts play a significant role in biotechnology. They are important production hosts for chemicals, enzymes and biopharmaceutical ingredients. This chapter outlines our current knowledge about the interrelation of the central carbon metabolism and various microbial production processes. It is obvious that every production process is inevitably connected to and dependent of the central carbon metabolism. For primary metabolites these relations are known and described in detail. However our knowledge how central carbon metabolism translates into flux and titer of secondary products and proteins are surprisingly scarce. The connection between central metabolic routes and specific product related pathways are described and metabolic engineering approaches towards enhanced production are discussed.

Sauer, M., Branduardi, P., Rußmayer, H., Marx, H., Porro, D., Mattanovich, D. (2014). Production of Metabolites and Heterologous Proteins. In J. Piskur, C. Compagno (a cura di), Molecular Mechanisms in Yeast Carbon Metabolism (pp. 299-326). Springer-Verlag Berlin Heidelberg [10.1007/978-3-642-55013-3_11].

Production of Metabolites and Heterologous Proteins

BRANDUARDI, PAOLA;PORRO, DANILO;
2014

Abstract

Yeasts play a significant role in biotechnology. They are important production hosts for chemicals, enzymes and biopharmaceutical ingredients. This chapter outlines our current knowledge about the interrelation of the central carbon metabolism and various microbial production processes. It is obvious that every production process is inevitably connected to and dependent of the central carbon metabolism. For primary metabolites these relations are known and described in detail. However our knowledge how central carbon metabolism translates into flux and titer of secondary products and proteins are surprisingly scarce. The connection between central metabolic routes and specific product related pathways are described and metabolic engineering approaches towards enhanced production are discussed.
Capitolo o saggio
yeast; metabolism; industrial biotechnology; metabolites; recombinant proteins
English
Molecular Mechanisms in Yeast Carbon Metabolism
Piskur, J; Compagno, C
2014
9783642550126
Springer-Verlag Berlin Heidelberg
299
326
Sauer, M., Branduardi, P., Rußmayer, H., Marx, H., Porro, D., Mattanovich, D. (2014). Production of Metabolites and Heterologous Proteins. In J. Piskur, C. Compagno (a cura di), Molecular Mechanisms in Yeast Carbon Metabolism (pp. 299-326). Springer-Verlag Berlin Heidelberg [10.1007/978-3-642-55013-3_11].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/49020
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