Yeasts play a significant role in biotechnology. They are important production hosts for chemicals, enzymes and biopharmaceutical ingredients. This chapter outlines our current knowledge about the interrelation of the central carbon metabolism and various microbial production processes. It is obvious that every production process is inevitably connected to and dependent of the central carbon metabolism. For primary metabolites these relations are known and described in detail. However our knowledge how central carbon metabolism translates into flux and titer of secondary products and proteins are surprisingly scarce. The connection between central metabolic routes and specific product related pathways are described and metabolic engineering approaches towards enhanced production are discussed.
Sauer, M., Branduardi, P., Rußmayer, H., Marx, H., Porro, D., Mattanovich, D. (2014). Production of Metabolites and Heterologous Proteins. In J. Piskur, C. Compagno (a cura di), Molecular Mechanisms in Yeast Carbon Metabolism (pp. 299-326). Springer-Verlag Berlin Heidelberg [10.1007/978-3-642-55013-3_11].
Production of Metabolites and Heterologous Proteins
BRANDUARDI, PAOLA;PORRO, DANILO;
2014
Abstract
Yeasts play a significant role in biotechnology. They are important production hosts for chemicals, enzymes and biopharmaceutical ingredients. This chapter outlines our current knowledge about the interrelation of the central carbon metabolism and various microbial production processes. It is obvious that every production process is inevitably connected to and dependent of the central carbon metabolism. For primary metabolites these relations are known and described in detail. However our knowledge how central carbon metabolism translates into flux and titer of secondary products and proteins are surprisingly scarce. The connection between central metabolic routes and specific product related pathways are described and metabolic engineering approaches towards enhanced production are discussed.
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