We compared by non-invasive technique the adaptive response of alveolar capillary network to edemagenic conditions (exercise and high altitude [HA, PIO2 107mmHg] in subjects with different resting sea level (SL) capillary blood volume (normalized to alveolar volume, Vc/Va): Group 1 (N=10, Vc/Va=16.1±6.8ml/L- mean±SD) and Group 2 (N=10, Vc/Va=25±7.7). In Group 1 Vc/Va remained unchanged in HA at rest and increased during exercise at SL (26.3±8.6) and HA (28.75±10.2); in Group 2 Vc/Va significantly decreased in HA (19±6) and did not increase in exercise at SL and HA. We hypothesize that Group2 exerts a tight control on Vc/Va being more exposed to the risk of lung edema due to inborn greater microvascular permeability. Conversely, Group 1 appears more resistant to lung edema given the large capillary recruitment in the most edemagenic condition. The 4-fold increase in frequency dependence of respiratory resistance in Group2 in HA stems for greater proneness for lung water perturbation compared to Group 1. © 2013 Elsevier B.V.

Bartesaghi, M., Beretta, E., Pollastri, L., Scotti, V., Mandolesi, G., Lanfranconi, F., et al. (2013). Inter-individual differences in control of alveolar capillary blood volume in exercise and hypoxia. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 190(1), 96-104 [10.1016/j.resp.2013.08.021].

Inter-individual differences in control of alveolar capillary blood volume in exercise and hypoxia

BERETTA, EGIDIO PAOLO;SCOTTI, VALENTINA;LANFRANCONI, FRANCESCA;MISEROCCHI, GIUSEPPE ANDREA
2013

Abstract

We compared by non-invasive technique the adaptive response of alveolar capillary network to edemagenic conditions (exercise and high altitude [HA, PIO2 107mmHg] in subjects with different resting sea level (SL) capillary blood volume (normalized to alveolar volume, Vc/Va): Group 1 (N=10, Vc/Va=16.1±6.8ml/L- mean±SD) and Group 2 (N=10, Vc/Va=25±7.7). In Group 1 Vc/Va remained unchanged in HA at rest and increased during exercise at SL (26.3±8.6) and HA (28.75±10.2); in Group 2 Vc/Va significantly decreased in HA (19±6) and did not increase in exercise at SL and HA. We hypothesize that Group2 exerts a tight control on Vc/Va being more exposed to the risk of lung edema due to inborn greater microvascular permeability. Conversely, Group 1 appears more resistant to lung edema given the large capillary recruitment in the most edemagenic condition. The 4-fold increase in frequency dependence of respiratory resistance in Group2 in HA stems for greater proneness for lung water perturbation compared to Group 1. © 2013 Elsevier B.V.
Articolo in rivista - Articolo scientifico
High altitude pulmonary edema, Lung diffusion, Lung ultrasound, Microvascular filtration, Respiratory impedance
English
2013
190
1
96
104
none
Bartesaghi, M., Beretta, E., Pollastri, L., Scotti, V., Mandolesi, G., Lanfranconi, F., et al. (2013). Inter-individual differences in control of alveolar capillary blood volume in exercise and hypoxia. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 190(1), 96-104 [10.1016/j.resp.2013.08.021].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/48954
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