OBJECTIVE: Evidence on the relationship between depression and clinical dimensions of schizophrenia remains limited. This cross-sectional study investigated the association between depression and Positive and Negative Syndrome Scale (PANSS) dimensions in people with schizophrenia spectrum disorders. METHODS: Trained assessors administered the PANSS to measure symptoms of schizophrenia and the Calgary Depression Scale for Schizophrenia to measure depression. The association of depression with overall PANSS score and related dimensions was investigated in multiple logistic regression analyses. RESULTS: We included 231 inpatients with schizophrenia spectrum disorders (mean age: 42.4 (SD: 12.9) years; men: 58.9%; mean overall PANSS score: 82.5 (SD: 20.1); drug-free or naïve: 39.3%), including 78 (33.8%) with clinically significant depressive symptoms. Depression was associated with higher overall (regression coefficient, SE: 0.029, 0.008; p < 0.001) and general psychopathology (regression coefficient, SE: 0.118, 0.023; p < 0.001) PANSS scores. We found an inverse relationship between depression and positive symptoms (regression coefficient, SE: -0.088, 0.028; p = 0.002). No association between depression and negative symptoms was found. CONCLUSION: Despite some limitations, our study shows that people affected by schizophrenia spectrum disorders with depression are likely to show more overall and general psychopathology symptoms but lower positive symptoms. Additional studies are needed to explore the generalizability of our findings.

Bartoli, F., Calabrese, A., Moretti, F., Castiglioni, M., Prestifilippo, L., De Pietra, A., et al. (2024). Exploring depression in people with schizophrenia spectrum disorders: A cross-sectional analysis of the clinical relationship with Positive and Negative Syndrome Scale dimensions. REVISTA BRASILEIRA DE PSIQUIATRIA, 46 [10.47626/1516-4446-2023-3418].

Exploring depression in people with schizophrenia spectrum disorders: A cross-sectional analysis of the clinical relationship with Positive and Negative Syndrome Scale dimensions

Bartoli, Francesco
Primo
;
Calabrese, Angela;Moretti, Federico;Castiglioni, Marta;Prestifilippo, Luca;De Pietra, Aldo;Gazzola, Marco;Crocamo, Cristina;Carrà, Giuseppe
Ultimo
;
Bachi, Bianca
Membro del Collaboration Group
;
Barbieri, Filippo Fabio
Membro del Collaboration Group
;
Bartoccetti, Alessandra
Membro del Collaboration Group
;
Bassetti, Carlo
Membro del Collaboration Group
;
Bernasconi, Gianna
Membro del Collaboration Group
;
Bommartini, Carlo
Membro del Collaboration Group
;
Bona, Paolo
Membro del Collaboration Group
;
Boniello, Federica
Membro del Collaboration Group
;
Callovini, Tommaso
Membro del Collaboration Group
;
Canestro, Aurelia
Membro del Collaboration Group
;
Capogrosso, Chiara Alessandra
Membro del Collaboration Group
;
Cavaleri, Daniele
Membro del Collaboration Group
;
Cioni, Riccardo Matteo
Membro del Collaboration Group
;
Colangelo, Francesca
Membro del Collaboration Group
;
Di Lella, Maria Elisa
Membro del Collaboration Group
;
Gianfelice, Letizia
Membro del Collaboration Group
;
Guzzi, Pierluca
Membro del Collaboration Group
;
Lauria, Giada
Membro del Collaboration Group
;
Limonta, Serena
Membro del Collaboration Group
;
Lucini Paioni, Susanna
Membro del Collaboration Group
;
Mauro, Stefano
Membro del Collaboration Group
;
Morello, Pietro
Membro del Collaboration Group
;
Morreale, Marco
Membro del Collaboration Group
;
Nasti, Christian
Membro del Collaboration Group
;
Palpella, Dario
Membro del Collaboration Group
;
Piacenti, Susanna
Membro del Collaboration Group
;
Re, Martina
Membro del Collaboration Group
;
Villa, Oliviero.
Membro del Collaboration Group
2024

Abstract

OBJECTIVE: Evidence on the relationship between depression and clinical dimensions of schizophrenia remains limited. This cross-sectional study investigated the association between depression and Positive and Negative Syndrome Scale (PANSS) dimensions in people with schizophrenia spectrum disorders. METHODS: Trained assessors administered the PANSS to measure symptoms of schizophrenia and the Calgary Depression Scale for Schizophrenia to measure depression. The association of depression with overall PANSS score and related dimensions was investigated in multiple logistic regression analyses. RESULTS: We included 231 inpatients with schizophrenia spectrum disorders (mean age: 42.4 (SD: 12.9) years; men: 58.9%; mean overall PANSS score: 82.5 (SD: 20.1); drug-free or naïve: 39.3%), including 78 (33.8%) with clinically significant depressive symptoms. Depression was associated with higher overall (regression coefficient, SE: 0.029, 0.008; p < 0.001) and general psychopathology (regression coefficient, SE: 0.118, 0.023; p < 0.001) PANSS scores. We found an inverse relationship between depression and positive symptoms (regression coefficient, SE: -0.088, 0.028; p = 0.002). No association between depression and negative symptoms was found. CONCLUSION: Despite some limitations, our study shows that people affected by schizophrenia spectrum disorders with depression are likely to show more overall and general psychopathology symptoms but lower positive symptoms. Additional studies are needed to explore the generalizability of our findings.
Articolo in rivista - Articolo scientifico
delusions; depression; hallucinations; psychopathology; Schizophrenia;
English
28-gen-2024
2024
46
e20233418
none
Bartoli, F., Calabrese, A., Moretti, F., Castiglioni, M., Prestifilippo, L., De Pietra, A., et al. (2024). Exploring depression in people with schizophrenia spectrum disorders: A cross-sectional analysis of the clinical relationship with Positive and Negative Syndrome Scale dimensions. REVISTA BRASILEIRA DE PSIQUIATRIA, 46 [10.47626/1516-4446-2023-3418].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/462299
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