Objective: Evidence on the relationship of depression with clinical dimensions of schizophrenia remains limited. This cross-sectional study aimed at exploring the association of depression with the Positive and Negative Syndrome Scale (PANSS) dimensions in people with schizophrenia spectrum disorders (SSD). Methods: Trained assessors administered PANSS to measure core symptoms of schizophrenia and the Calgary Depression Scale for Schizophrenia (CDSS) to measure depressive features. Multiple logistic regression analyses were carried out to analyse the association of depression with PANSS overall score and related dimensions. Results: We included 231 inpatients with SSD (mean age:42.4±12.9 years; males: 58.9%; mean PANSS overall score:82.5±20.1; drug-free or naïve: 39.3%), including 78 (33.8%) with clinically significant depressive symptoms. Depression was associated with higher overall (regression coefficient [coeff.], standard error [SE]: 0.029, 0.008; p<0.001) and General Psychopathology (coeff., SE: 0.118, 0.023; p<0.001) PANSS scores. We found an inverse relationship between depression and positive symptoms (coeff., SE: -0.088, 0.028; p=0.002). No association between depressive and negative symptoms was estimated. Conclusions: Despite some limitations, our study shows that people affected by SSD with depressive features are likely to show more overall and general psychopathology symptoms, though lower positive symptoms. Additional studies are needed to explore the generalizability of our findings.
Bartoli, F., Calabrese, A., Moretti, F., Castiglioni, M., Prestifilippo, L., De Pietra, A., et al. (2024). Exploring depression in people with schizophrenia spectrum disorders: A cross-sectional analysis of the clinical relationship with Positive and Negative Syndrome Scale dimensions. REVISTA BRASILEIRA DE PSIQUIATRIA [10.47626/1516-4446-2023-3418].
Exploring depression in people with schizophrenia spectrum disorders: A cross-sectional analysis of the clinical relationship with Positive and Negative Syndrome Scale dimensions
Bartoli, FrancescoPrimo
;Calabrese, Angela;Moretti, Federico;Castiglioni, Marta;Prestifilippo, Luca;De Pietra, Aldo;Gazzola, Marco;Crocamo, Cristina;Carrà, GiuseppeUltimo
;Bachi, BiancaMembro del Collaboration Group
;Barbieri, Filippo FabioMembro del Collaboration Group
;Bartoccetti, AlessandraMembro del Collaboration Group
;Bassetti, CarloMembro del Collaboration Group
;Bernasconi, GiannaMembro del Collaboration Group
;Bommartini, CarloMembro del Collaboration Group
;Bona, PaoloMembro del Collaboration Group
;Boniello, FedericaMembro del Collaboration Group
;Callovini, TommasoMembro del Collaboration Group
;Canestro, AureliaMembro del Collaboration Group
;Capogrosso, Chiara AlessandraMembro del Collaboration Group
;Cavaleri, DanieleMembro del Collaboration Group
;Cioni, Riccardo MatteoMembro del Collaboration Group
;Colangelo, FrancescaMembro del Collaboration Group
;Di Lella, Maria ElisaMembro del Collaboration Group
;Gianfelice, LetiziaMembro del Collaboration Group
;Guzzi, PierlucaMembro del Collaboration Group
;Lauria, GiadaMembro del Collaboration Group
;Limonta, SerenaMembro del Collaboration Group
;Lucini Paioni, SusannaMembro del Collaboration Group
;Mauro, StefanoMembro del Collaboration Group
;Morello, PietroMembro del Collaboration Group
;Morreale, MarcoMembro del Collaboration Group
;Nasti, ChristianMembro del Collaboration Group
;Palpella, DarioMembro del Collaboration Group
;Piacenti, SusannaMembro del Collaboration Group
;Re, MartinaMembro del Collaboration Group
;Villa, Oliviero.Membro del Collaboration Group
2024
Abstract
Objective: Evidence on the relationship of depression with clinical dimensions of schizophrenia remains limited. This cross-sectional study aimed at exploring the association of depression with the Positive and Negative Syndrome Scale (PANSS) dimensions in people with schizophrenia spectrum disorders (SSD). Methods: Trained assessors administered PANSS to measure core symptoms of schizophrenia and the Calgary Depression Scale for Schizophrenia (CDSS) to measure depressive features. Multiple logistic regression analyses were carried out to analyse the association of depression with PANSS overall score and related dimensions. Results: We included 231 inpatients with SSD (mean age:42.4±12.9 years; males: 58.9%; mean PANSS overall score:82.5±20.1; drug-free or naïve: 39.3%), including 78 (33.8%) with clinically significant depressive symptoms. Depression was associated with higher overall (regression coefficient [coeff.], standard error [SE]: 0.029, 0.008; p<0.001) and General Psychopathology (coeff., SE: 0.118, 0.023; p<0.001) PANSS scores. We found an inverse relationship between depression and positive symptoms (coeff., SE: -0.088, 0.028; p=0.002). No association between depressive and negative symptoms was estimated. Conclusions: Despite some limitations, our study shows that people affected by SSD with depressive features are likely to show more overall and general psychopathology symptoms, though lower positive symptoms. Additional studies are needed to explore the generalizability of our findings.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.