The Bereitschaftspotential (BP), a scalp potential recorded in humans during action preparation, is characterized by a slow amplitude increase over fronto-central regions as action execution approaches. We recorded TMS evoked-potentials (TEP) stimulating the supplementary motor area (SMA) at different time-points during a Go/No-Go task to assess whether and how cortical excitability and connectivity of this region change as the BP increases. When approaching BP peak, left SMA reactivity resulted greater. Concurrently, its effective connectivity increased with the left occipital areas, while it decreased with the right inferior frontal gyrus, indicating a fast reconfiguration of cortical networks during the preparation of the forthcoming action. Functional connectivity patterns supported these findings, suggesting a critical role of frequency-specific inter-areal interactions in implementing top-down mechanisms in the sensorimotor system prior to action. These findings reveal that BP time-course reflects quantitative and qualitative changes in SMA communication patterns that shape mechanisms involved in motor readiness.

Bianco, V., Arrigoni, E., Di Russo, F., Romero Lauro, L., Pisoni, A. (2023). Top-down reconfiguration of SMA cortical connectivity during action preparation. ISCIENCE, 26(8) [10.1016/j.isci.2023.107430].

Top-down reconfiguration of SMA cortical connectivity during action preparation

Arrigoni, Eleonora
Co-primo
;
Romero Lauro, Leonor Josefina;Pisoni, Alberto
Ultimo
2023

Abstract

The Bereitschaftspotential (BP), a scalp potential recorded in humans during action preparation, is characterized by a slow amplitude increase over fronto-central regions as action execution approaches. We recorded TMS evoked-potentials (TEP) stimulating the supplementary motor area (SMA) at different time-points during a Go/No-Go task to assess whether and how cortical excitability and connectivity of this region change as the BP increases. When approaching BP peak, left SMA reactivity resulted greater. Concurrently, its effective connectivity increased with the left occipital areas, while it decreased with the right inferior frontal gyrus, indicating a fast reconfiguration of cortical networks during the preparation of the forthcoming action. Functional connectivity patterns supported these findings, suggesting a critical role of frequency-specific inter-areal interactions in implementing top-down mechanisms in the sensorimotor system prior to action. These findings reveal that BP time-course reflects quantitative and qualitative changes in SMA communication patterns that shape mechanisms involved in motor readiness.
Articolo in rivista - Articolo scientifico
Biological sciences; Methodology in biological sciences; Neurology;
English
20-lug-2023
2023
26
8
107430
open
Bianco, V., Arrigoni, E., Di Russo, F., Romero Lauro, L., Pisoni, A. (2023). Top-down reconfiguration of SMA cortical connectivity during action preparation. ISCIENCE, 26(8) [10.1016/j.isci.2023.107430].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/450278
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