The development of new advanced constructs resembling structural and functional properties of human organs and tissues requires a deep knowledge of the morphological and biochemical properties of the extracellular matrices (ECM), and the capacity to reproduce them. Manufacturing technologies like 3D printing and bioprinting represent valuable tools for this purpose. This review will describe how morphological and biochemical properties of ECM change in different tissues, organs, healthy and pathological states, and how ECM mimics with the required properties can be generated by 3D printing and bioprinting. The review describes and classifies the polymeric materials of natural and synthetic origin exploited to generate the hydrogels acting as "inks" in the 3D printing process, with particular emphasis on their functionalization allowing crosslinking and conjugation with signaling molecules to develop bio-responsive and bio-instructive ECM mimics.

Cadamuro, F., Nicotra, F., Russo, L. (2023). 3D printed tissue models: From hydrogels to biomedical applications. JOURNAL OF CONTROLLED RELEASE, 354, 726-745 [10.1016/j.jconrel.2023.01.048].

3D printed tissue models: From hydrogels to biomedical applications

Cadamuro, F;Nicotra, F;Russo, L
2023

Abstract

The development of new advanced constructs resembling structural and functional properties of human organs and tissues requires a deep knowledge of the morphological and biochemical properties of the extracellular matrices (ECM), and the capacity to reproduce them. Manufacturing technologies like 3D printing and bioprinting represent valuable tools for this purpose. This review will describe how morphological and biochemical properties of ECM change in different tissues, organs, healthy and pathological states, and how ECM mimics with the required properties can be generated by 3D printing and bioprinting. The review describes and classifies the polymeric materials of natural and synthetic origin exploited to generate the hydrogels acting as "inks" in the 3D printing process, with particular emphasis on their functionalization allowing crosslinking and conjugation with signaling molecules to develop bio-responsive and bio-instructive ECM mimics.
Articolo in rivista - Articolo scientifico
3D bioprinting; 3D tissue models; biomaterials; click chemistry; ECM mimics
English
26-gen-2023
2023
354
726
745
open
Cadamuro, F., Nicotra, F., Russo, L. (2023). 3D printed tissue models: From hydrogels to biomedical applications. JOURNAL OF CONTROLLED RELEASE, 354, 726-745 [10.1016/j.jconrel.2023.01.048].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/441080
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