In S. cerevisiae, the Ras/cAMP/PKA pathway is involved in the regulation of cell growth and proliferation in response to nutritional sensing and stress conditions. The pathway is tightly regulated by multiple feedback loops that can lead the second messenger cAMP to oscillatory regimes. In this paper we analyze the dynamics of cAMP by performing stochastic simulations of a mechanistic model of the Ras/cAMP/PKA pathway, to consider the effects of the deletion of phosphodiesterases (the enzymes catalyzing the degradation of cAMP, which represent the major negative feedback in this pathway) and the role of the intracellular ratio of guanine nucleotides (GTP/GDP).
Pescini, D., Cazzaniga, P., Besozzi, D., Mauri, G., Colombo, S., Martegani, E. (2011). Investigating oscillatory regimens in the Ras/cAMP/PKA pathway in S. cerevisiae: the role of feedback control mechanisms. In Proc. 8th Int. Workshop on Computational Systems Biology, WCSB 2011 (pp.33-36). Tampere : Tampere International Center for Signal Processing.
Investigating oscillatory regimens in the Ras/cAMP/PKA pathway in S. cerevisiae: the role of feedback control mechanisms
PESCINI, DARIO;BESOZZI, DANIELA;MAURI, GIANCARLO;COLOMBO, SONIA;MARTEGANI, ENZO
2011
Abstract
In S. cerevisiae, the Ras/cAMP/PKA pathway is involved in the regulation of cell growth and proliferation in response to nutritional sensing and stress conditions. The pathway is tightly regulated by multiple feedback loops that can lead the second messenger cAMP to oscillatory regimes. In this paper we analyze the dynamics of cAMP by performing stochastic simulations of a mechanistic model of the Ras/cAMP/PKA pathway, to consider the effects of the deletion of phosphodiesterases (the enzymes catalyzing the degradation of cAMP, which represent the major negative feedback in this pathway) and the role of the intracellular ratio of guanine nucleotides (GTP/GDP).
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