Background: We explored the relation between blood concentrations of monocyte/lymphocyte subsets and carotid artery plaque macrophage content, measured by positron emission tomography (PET) with 11C-PK11195. Methods and results: In 9 patients with carotid plaques we performed 11C-PK11195-PET/computed tomography angiography imaging and measurement of absolute concentrations and frequencies of circulating monocytes and T-cell subsets. Plaque standardized uptake value (SUV) for 11C-PK11195 was negatively correlated with concentrations of total monocytes (r = −0.58, p = 0.05) and CD14++CD16−HLA-DR+ classical subset (r = −0.82, p = 0.005). These correlations hold true also in relation to plaque target to background ratio. No correlation was observed between plaque SUV and CD3+T lymphocytes, CD4+T lymphocytes nor with activated CD3+CD4+T cells expressing HLA-DR. Conclusions: We first demonstrated a reduction in the absolute concentration of monocytes and particularly in classical monocytes expressing HLA-DR in the presence of an increased uptake of 11C-PK11195 in carotid plaques. The present work, despite being a pilot study comprising only a small number of subjects provides new insights in the search for specific cellular biomarkers with potential diagnostic and prognostic value in patients with a known carotid plaque.

Ammirati, E., Moroni, F., Magnoni, M., Busnardo, E., Di Terlizzi, S., Villa, C., et al. (2018). Carotid artery plaque uptake of 11C-PK11195 inversely correlates with circulating monocytes and classical CD14++CD16− monocytes expressing HLA-DR. INTERNATIONAL JOURNAL OF CARDIOLOGY. HEART & VASCULATURE, 21, 32-35 [10.1016/j.ijcha.2018.09.005].

Carotid artery plaque uptake of 11C-PK11195 inversely correlates with circulating monocytes and classical CD14++CD16− monocytes expressing HLA-DR

Presotto L.;
2018

Abstract

Background: We explored the relation between blood concentrations of monocyte/lymphocyte subsets and carotid artery plaque macrophage content, measured by positron emission tomography (PET) with 11C-PK11195. Methods and results: In 9 patients with carotid plaques we performed 11C-PK11195-PET/computed tomography angiography imaging and measurement of absolute concentrations and frequencies of circulating monocytes and T-cell subsets. Plaque standardized uptake value (SUV) for 11C-PK11195 was negatively correlated with concentrations of total monocytes (r = −0.58, p = 0.05) and CD14++CD16−HLA-DR+ classical subset (r = −0.82, p = 0.005). These correlations hold true also in relation to plaque target to background ratio. No correlation was observed between plaque SUV and CD3+T lymphocytes, CD4+T lymphocytes nor with activated CD3+CD4+T cells expressing HLA-DR. Conclusions: We first demonstrated a reduction in the absolute concentration of monocytes and particularly in classical monocytes expressing HLA-DR in the presence of an increased uptake of 11C-PK11195 in carotid plaques. The present work, despite being a pilot study comprising only a small number of subjects provides new insights in the search for specific cellular biomarkers with potential diagnostic and prognostic value in patients with a known carotid plaque.
Articolo in rivista - Articolo scientifico
Scientifica
11; C-PK11195 uptake; Atherosclerosis; Carotid plaque; Classical monocytes; Positron emission tomography;
English
Ammirati, E., Moroni, F., Magnoni, M., Busnardo, E., Di Terlizzi, S., Villa, C., et al. (2018). Carotid artery plaque uptake of 11C-PK11195 inversely correlates with circulating monocytes and classical CD14++CD16− monocytes expressing HLA-DR. INTERNATIONAL JOURNAL OF CARDIOLOGY. HEART & VASCULATURE, 21, 32-35 [10.1016/j.ijcha.2018.09.005].
Ammirati, E; Moroni, F; Magnoni, M; Busnardo, E; Di Terlizzi, S; Villa, C; Sizzano, F; Scotti, I; Palini, A; Presotto, L; Bettinardi, V; Spagnolo, P; Besana, F; Gianolli, L; Rimoldi, O; Camici, P
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/380385
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