Cyclic peptidomimetics are attracting structures to obtain a distinct, bioactive conformation. Even more attractive are sugar-containing cyclic peptidomimetics which present turn structures induced by the pyranose ring when incorporated in cyclic peptides. The use of a new and versatile saccharidic scaffold to achieve sugar-based peptidomimetics is here reported together with the successful synthesis of diastereomerically pure cyclic SAA peptidomimetics 15 and 16.

Altamura, M., Dragoni, E., Infantino Angela, S., Legnani, L., Ludbrook Steve, B., Menchi, G., et al. (2009). Cyclic glycopeptidomimetics through a versatile sugar-based scaffold. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(14), 3841-3844 [10.1016/j.bmcl.2009.04.008].

Cyclic glycopeptidomimetics through a versatile sugar-based scaffold

LEGNANI, LAURA;
2009

Abstract

Cyclic peptidomimetics are attracting structures to obtain a distinct, bioactive conformation. Even more attractive are sugar-containing cyclic peptidomimetics which present turn structures induced by the pyranose ring when incorporated in cyclic peptides. The use of a new and versatile saccharidic scaffold to achieve sugar-based peptidomimetics is here reported together with the successful synthesis of diastereomerically pure cyclic SAA peptidomimetics 15 and 16.
Articolo in rivista - Articolo scientifico
Glycopeptides; Integrins; Peptidomimetics; Sugar aminoacids; Tachykinins;
English
3841
3844
4
Altamura, M., Dragoni, E., Infantino Angela, S., Legnani, L., Ludbrook Steve, B., Menchi, G., et al. (2009). Cyclic glycopeptidomimetics through a versatile sugar-based scaffold. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(14), 3841-3844 [10.1016/j.bmcl.2009.04.008].
Altamura, M; Dragoni, E; Infantino Angela, S; Legnani, L; Ludbrook Steve, B; Menchi, G; Toma, L; Nativi, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/352021
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