(Chemical Equation Presented) Conformation analysis and synthesis of 2, a hydrolytically stable mimetic of the tumour antigen, GM3 lactone ganglioside (1 a), is reported (see figure for superimposed images of 1 a and 2). The interaction between 2 and wheat germ agglutinin lectin showed that 2 is a veritable mimetic of a sialyl-containing saccharide. DOPC/DOPE liposomes containing thioether 3 were also prepared and characterized; these could prove to be promising carriers for the production of monoclonal antibodies.

Toma, L., Di Cola, E., Ienco, A., Legnani, L., Lunghi, C., Moneti, G., et al. (2007). Synthesis, conformational studies, binding assessment and liposome insertion of a thioether-bridged mimetic of the antigen GM3 ganglioside lactone. CHEMBIOCHEM, 8(14), 1646-1649 [10.1002/cbic.200700208].

Synthesis, conformational studies, binding assessment and liposome insertion of a thioether-bridged mimetic of the antigen GM3 ganglioside lactone

LEGNANI, LAURA;
2007

Abstract

(Chemical Equation Presented) Conformation analysis and synthesis of 2, a hydrolytically stable mimetic of the tumour antigen, GM3 lactone ganglioside (1 a), is reported (see figure for superimposed images of 1 a and 2). The interaction between 2 and wheat germ agglutinin lectin showed that 2 is a veritable mimetic of a sialyl-containing saccharide. DOPC/DOPE liposomes containing thioether 3 were also prepared and characterized; these could prove to be promising carriers for the production of monoclonal antibodies.
Articolo in rivista - Articolo scientifico
Drug design; Glycoconjugates; Liposomes; Mimetic; Selectins;
English
1646
1649
4
Toma, L., Di Cola, E., Ienco, A., Legnani, L., Lunghi, C., Moneti, G., et al. (2007). Synthesis, conformational studies, binding assessment and liposome insertion of a thioether-bridged mimetic of the antigen GM3 ganglioside lactone. CHEMBIOCHEM, 8(14), 1646-1649 [10.1002/cbic.200700208].
Toma, L; Di Cola, E; Ienco, A; Legnani, L; Lunghi, C; Moneti, G; Richichi, B; Ristori, S; Dell'Atti, D; Nativi, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/351986
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