Carbohydrate mimics have been studied for a long time as useful sugar substitutes, both in the investigation of biological events and in the treatment of sugar-related diseases. Here we report further evaluation of the capabilities of inositols as carbohydrate substitutes. The conformational features of an inositol-model of a simplified repeating unit corresponding to the capsular polysaccharide of Streptococcus pneumoniae 19F has been evaluated by computational analysis, and compared to the native repeating unit. The inositol mimic was synthesized, and its experimental spectroscopic data allowed for verification of the theoretical results.

Catelani, G., D'Andrea, F., Guazzelli, L., Griselli, A., Testi, N., Chiacchio, M., et al. (2017). Synthesis and conformational analysis of a simplified inositol-model of the Streptococcus pneumoniae 19F capsular polysaccharide repeating unit. CARBOHYDRATE RESEARCH, 443-444, 29-36 [10.1016/j.carres.2017.03.012].

Synthesis and conformational analysis of a simplified inositol-model of the Streptococcus pneumoniae 19F capsular polysaccharide repeating unit

LEGNANI, LAURA;
2017

Abstract

Carbohydrate mimics have been studied for a long time as useful sugar substitutes, both in the investigation of biological events and in the treatment of sugar-related diseases. Here we report further evaluation of the capabilities of inositols as carbohydrate substitutes. The conformational features of an inositol-model of a simplified repeating unit corresponding to the capsular polysaccharide of Streptococcus pneumoniae 19F has been evaluated by computational analysis, and compared to the native repeating unit. The inositol mimic was synthesized, and its experimental spectroscopic data allowed for verification of the theoretical results.
Articolo in rivista - Articolo scientifico
Carbohydrate mimic; Inositol; Streptococcus pneumoniae; Vaccine;
English
29
36
8
Catelani, G., D'Andrea, F., Guazzelli, L., Griselli, A., Testi, N., Chiacchio, M., et al. (2017). Synthesis and conformational analysis of a simplified inositol-model of the Streptococcus pneumoniae 19F capsular polysaccharide repeating unit. CARBOHYDRATE RESEARCH, 443-444, 29-36 [10.1016/j.carres.2017.03.012].
Catelani, G; D'Andrea, F; Guazzelli, L; Griselli, A; Testi, N; Chiacchio, M; Legnani, L; Toma, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/351940
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