Pyridine and pyrimidine derivatives have received great interest in recent pharmacological research, being effective in the treatment of various malignancies, such as myeloid leukemia, breast cancer and idiopathic pulmonary fibrosis. Most of the FDA approved drugs show a pyridine or pyrimidine core bearing different substituents. The aim of this review is to describe the most recent reports in this field, with reference to the newly discovered pyridineor pyrimidine-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding benzo-fused heterocyclic compounds, i.e. quinolines and quinazolines, are also reported.

Chiacchio, M., Iannazzo, D., Romeo, R., Giofre, S., Legnani, L. (2019). Pyridine and pyrimidine derivatives as privileged scaffolds in biologically active agents. CURRENT MEDICINAL CHEMISTRY, 26(40), 7166-7195 [10.2174/0929867325666180904125400].

Pyridine and pyrimidine derivatives as privileged scaffolds in biologically active agents

Legnani L.
2019

Abstract

Pyridine and pyrimidine derivatives have received great interest in recent pharmacological research, being effective in the treatment of various malignancies, such as myeloid leukemia, breast cancer and idiopathic pulmonary fibrosis. Most of the FDA approved drugs show a pyridine or pyrimidine core bearing different substituents. The aim of this review is to describe the most recent reports in this field, with reference to the newly discovered pyridineor pyrimidine-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding benzo-fused heterocyclic compounds, i.e. quinolines and quinazolines, are also reported.
Recensione in rivista
Biological activities; Molecular modeling; Nitrogenated heterocycles; Pyridine; Pyrimidine; Synthesis;
English
7166
7195
30
Chiacchio, M., Iannazzo, D., Romeo, R., Giofre, S., Legnani, L. (2019). Pyridine and pyrimidine derivatives as privileged scaffolds in biologically active agents. CURRENT MEDICINAL CHEMISTRY, 26(40), 7166-7195 [10.2174/0929867325666180904125400].
Chiacchio, M; Iannazzo, D; Romeo, R; Giofre, S; Legnani, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/351924
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