A series of N-(2,4-difluorophenyl)-N′-heptyl-N′-{4- [(substituted)-pyridazin-3-yl)thio]pentyl}urea derivatives having a phenyl ring at positions 5 and/or at position 6 of the heterocycle, as well as the corresponding sulfones, were synthesized. Their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. Theoretical studies were performed to correlate their activity to their structural features.

Gelain, A., Bettinelli, I., Barlocco, D., KWON Byoung, M., JEONG Tae, S., IM Kyung, R., et al. (2006). Ureidopyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors. SCIENTIA PHARMACEUTICA, 74(3), 85-97 [10.3797/scipharm.2006.74.85].

Ureidopyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors

LEGNANI, LAURA;
2006

Abstract

A series of N-(2,4-difluorophenyl)-N′-heptyl-N′-{4- [(substituted)-pyridazin-3-yl)thio]pentyl}urea derivatives having a phenyl ring at positions 5 and/or at position 6 of the heterocycle, as well as the corresponding sulfones, were synthesized. Their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. Theoretical studies were performed to correlate their activity to their structural features.
Articolo in rivista - Articolo scientifico
ACAT inhibitors; Hypercholesterolemia; Pyridazine derivatives; Ureido derivatives;
English
85
97
13
Gelain, A., Bettinelli, I., Barlocco, D., KWON Byoung, M., JEONG Tae, S., IM Kyung, R., et al. (2006). Ureidopyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors. SCIENTIA PHARMACEUTICA, 74(3), 85-97 [10.3797/scipharm.2006.74.85].
Gelain, A; Bettinelli, I; Barlocco, D; KWON Byoung, M; JEONG Tae, S; IM Kyung, R; Legnani, L; Toma, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/351886
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