Background: Long-term pulmonary sequelae following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia are not yet confirmed; however, preliminary observations suggest a possible relevant clinical, functional, and radiological impairment. Objectives: The aim of this study was to identify and characterize pulmonary sequelae caused by SARS-CoV-2 pneumonia at 6-month follow-up. Methods: In this multicentre, prospective, observational cohort study, patients hospitalized for SARS-CoV-2 pneumonia and without prior diagnosis of structural lung diseases were stratified by maximum ventilatory support ("oxygen only,""continuous positive airway pressure,"and "invasive mechanical ventilation") and followed up at 6 months from discharge. Pulmonary function tests and diffusion capacity for carbon monoxide (DLCO), 6-min walking test, chest X-ray, physical examination, and modified Medical Research Council (mMRC) dyspnoea score were collected. Results: Between March and June 2020, 312 patients were enrolled (83, 27% women; median interquartile range age 61.1 [53.4, 69.3] years). The parameters that showed the highest rate of impairment were DLCO and chest X-ray, in 46% and 25% of patients, respectively. However, only a minority of patients reported dyspnoea (31%), defined as mMRC ≥1, or showed restrictive ventilatory defects (9%). In the logistic regression model, having asthma as a comorbidity was associated with DLCO impairment at follow-up, while prophylactic heparin administration during hospitalization appeared as a protective factor. The need for invasive ventilatory support during hospitalization was associated with chest imaging abnormalities. Conclusions: DLCO and radiological assessment appear to be the most sensitive tools to monitor patients with the coronavirus disease 2019 (COVID-19) during follow-up. Future studies with longer follow-up are warranted to better understand pulmonary sequelae.
Faverio, P., Luppi, F., Rebora, P., Busnelli, S., Stainer, A., Catalano, M., et al. (2021). Six-Month Pulmonary Impairment after Severe COVID-19: A Prospective, Multicentre Follow-Up Study. RESPIRATION, 100(11), 1078-1087 [10.1159/000518141].
|Citazione:||Faverio, P., Luppi, F., Rebora, P., Busnelli, S., Stainer, A., Catalano, M., et al. (2021). Six-Month Pulmonary Impairment after Severe COVID-19: A Prospective, Multicentre Follow-Up Study. RESPIRATION, 100(11), 1078-1087 [10.1159/000518141].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||No|
|Titolo:||Six-Month Pulmonary Impairment after Severe COVID-19: A Prospective, Multicentre Follow-Up Study|
|Autori:||Faverio, P; Luppi, F; Rebora, P; Busnelli, S; Stainer, A; Catalano, M; Parachini, L; Monzani, A; Galimberti, S; Bini, F; Bodini, B; Betti, M; De Giacomi, F; Scarpazza, P; Oggionni, E; Scartabellati, A; Bilucaglia, L; Ceruti, P; Modina, D; Harari, S; Caminati, A; Valsecchi, M; Bellani, G; Foti, G; Pesci, A|
FAVERIO, PAOLA (Corresponding)
|Data di pubblicazione:||2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000518141|
|Appare nelle tipologie:||01 - Articolo su rivista|