IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishBackground: Long-term pulmonary sequelae following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia are not yet confirmed; however, preliminary observations suggest a possible relevant clinical, functional, and radiological impairment. Objectives: The aim of this study was to identify and characterize pulmonary sequelae caused by SARS-CoV-2 pneumonia at 6-month follow-up. Methods: In this multicentre, prospective, observational cohort study, patients hospitalized for SARS-CoV-2 pneumonia and without prior diagnosis of structural lung diseases were stratified by maximum ventilatory support ("oxygen only,""continuous positive airway pressure,"and "invasive mechanical ventilation") and followed up at 6 months from discharge. Pulmonary function tests and diffusion capacity for carbon monoxide (DLCO), 6-min walking test, chest X-ray, physical examination, and modified Medical Research Council (mMRC) dyspnoea score were collected. Results: Between March and June 2020, 312 patients were enrolled (83, 27% women; median interquartile range age 61.1 [53.4, 69.3] years). The parameters that showed the highest rate of impairment were DLCO and chest X-ray, in 46% and 25% of patients, respectively. However, only a minority of patients reported dyspnoea (31%), defined as mMRC ≥1, or showed restrictive ventilatory defects (9%). In the logistic regression model, having asthma as a comorbidity was associated with DLCO impairment at follow-up, while prophylactic heparin administration during hospitalization appeared as a protective factor. The need for invasive ventilatory support during hospitalization was associated with chest imaging abnormalities. Conclusions: DLCO and radiological assessment appear to be the most sensitive tools to monitor patients with the coronavirus disease 2019 (COVID-19) during follow-up. Future studies with longer follow-up are warranted to better understand pulmonary sequelae.
Faverio, P., Luppi, F., Rebora, P., Busnelli, S., Stainer, A., Catalano, M., et al. (2021). Six-Month Pulmonary Impairment after Severe COVID-19: A Prospective, Multicentre Follow-Up Study. RESPIRATION, 100(11), 1078-1087 [10.1159/000518141].
| Citazione: | Faverio, P., Luppi, F., Rebora, P., Busnelli, S., Stainer, A., Catalano, M., et al. (2021). Six-Month Pulmonary Impairment after Severe COVID-19: A Prospective, Multicentre Follow-Up Study. RESPIRATION, 100(11), 1078-1087 [10.1159/000518141]. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | No | |
| Titolo: | Six-Month Pulmonary Impairment after Severe COVID-19: A Prospective, Multicentre Follow-Up Study | |
| Autori: | Faverio, P; Luppi, F; Rebora, P; Busnelli, S; Stainer, A; Catalano, M; Parachini, L; Monzani, A; Galimberti, S; Bini, F; Bodini, B; Betti, M; De Giacomi, F; Scarpazza, P; Oggionni, E; Scartabellati, A; Bilucaglia, L; Ceruti, P; Modina, D; Harari, S; Caminati, A; Valsecchi, M; Bellani, G; Foti, G; Pesci, A | |
| Autori: | ||
| Data di pubblicazione: | 2021 | |
| Lingua: | English | |
| Rivista: | RESPIRATION | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1159/000518141 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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