To investigate temperament as an early risk marker for autism spectrum disorder (ASD), we examined parent-reported temperament for high-risk (HR, n = 170) and low-risk (LR, n = 77) siblings at 8, 14, and 24 months. Diagnostic assessment was performed at 36 months. Group-based analyses showed linear risk gradients, with more atypical temperament for HR-ASD, followed by HR-Atypical, HR-Typical, and LR siblings. Temperament differed significantly between outcome groups (0.03 ≤ ηp2 ≤ 0.34). Machine learning analyses showed that, at an individual level, HR-ASD siblings could not be identified accurately, whereas HR infants without ASD could. Our results emphasize the discrepancy between group-based and individual-based predictions and suggest that while temperament does not facilitate early identification of ASD individually, it may help identify HR infants who do not develop ASD.

Pijl, M., Bussu, G., Charman, T., Johnson, M., Jones, E., Pasco, G., et al. (2019). Temperament as an Early Risk Marker for Autism Spectrum Disorders? A Longitudinal Study of High-Risk and Low-Risk Infants. JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 49(5), 1825-1836 [10.1007/s10803-018-3855-8].

Temperament as an Early Risk Marker for Autism Spectrum Disorders? A Longitudinal Study of High-Risk and Low-Risk Infants

Salomone E.;
2019

Abstract

To investigate temperament as an early risk marker for autism spectrum disorder (ASD), we examined parent-reported temperament for high-risk (HR, n = 170) and low-risk (LR, n = 77) siblings at 8, 14, and 24 months. Diagnostic assessment was performed at 36 months. Group-based analyses showed linear risk gradients, with more atypical temperament for HR-ASD, followed by HR-Atypical, HR-Typical, and LR siblings. Temperament differed significantly between outcome groups (0.03 ≤ ηp2 ≤ 0.34). Machine learning analyses showed that, at an individual level, HR-ASD siblings could not be identified accurately, whereas HR infants without ASD could. Our results emphasize the discrepancy between group-based and individual-based predictions and suggest that while temperament does not facilitate early identification of ASD individually, it may help identify HR infants who do not develop ASD.
Articolo in rivista - Articolo scientifico
Autism spectrum disorder; High-risk; Longitudinal; Machine learning; Temperament
English
2019
49
5
1825
1836
open
Pijl, M., Bussu, G., Charman, T., Johnson, M., Jones, E., Pasco, G., et al. (2019). Temperament as an Early Risk Marker for Autism Spectrum Disorders? A Longitudinal Study of High-Risk and Low-Risk Infants. JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 49(5), 1825-1836 [10.1007/s10803-018-3855-8].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/336739
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