Cancer patients present with abnormalities of coagulation tests, reflecting a hypercoagulable state, often asso- ciated with a high incidence of thrombotic complications and poor disease prognosis. Different degrees of blood clotting abnormalities are described in diverse cancers, depending on tumor types and stage. The mechanisms of hemostasis that are critically involved in thrombosis are also implicated in tumor progression, angiogenesis, and metastatic spread. In this review, we summarize the results of published studies and focus on ongoing research and future directions of clotting factors and clotting activation bioproducts as biomarkers for cancer disease diagnosis and in cancer risk prediction.

Marchetti, M., Falanga, A. (2020). Hemostatic biomarkers in occult cancer and cancer risk prediction. THROMBOSIS RESEARCH, 191(supplement 1), S37-S42 [10.1016/S0049-3848(20)30395-9].

Hemostatic biomarkers in occult cancer and cancer risk prediction

Marchetti M.
;
Falanga A.
2020

Abstract

Cancer patients present with abnormalities of coagulation tests, reflecting a hypercoagulable state, often asso- ciated with a high incidence of thrombotic complications and poor disease prognosis. Different degrees of blood clotting abnormalities are described in diverse cancers, depending on tumor types and stage. The mechanisms of hemostasis that are critically involved in thrombosis are also implicated in tumor progression, angiogenesis, and metastatic spread. In this review, we summarize the results of published studies and focus on ongoing research and future directions of clotting factors and clotting activation bioproducts as biomarkers for cancer disease diagnosis and in cancer risk prediction.
Articolo in rivista - Articolo scientifico
Cancer diagnosis; Cancer risk; Hemostasis; Hemostatic biomarkers; Procoagulants; Tumor cells
English
S37
S42
Marchetti, M., Falanga, A. (2020). Hemostatic biomarkers in occult cancer and cancer risk prediction. THROMBOSIS RESEARCH, 191(supplement 1), S37-S42 [10.1016/S0049-3848(20)30395-9].
Marchetti, M; Falanga, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/322123
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