Small cell lung cancer (SCLC) is one of the deadliest thoracic neoplasms, in part due to its fast doubling time and early metastatic spread. Historically, cytotoxic chemotherapy consisting of platinum–etoposide or anthracycline-based regimens has demonstrated a high response rate, but early chemoresistance leads to a poor prognosis in advanced SCLC. Only a fraction of patients with limited-disease can be cured by chemo-radiotherapy. Given the disappointing survival rates in advanced SCLC, new cytotoxic agents are eagerly awaited. Unfortunately, few novel chemotherapy drugs have been developed in the latest decades. This review describes the results and potential application in the clinical practice of novel chemotherapy agents for SCLC.

Cortinovis, D., Bidoli, P., Canova, S., Colonese, F., Gemelli, M., Lavitrano, M., et al. (2021). Novel cytotoxic chemotherapies in small cell lung carcinoma. CANCERS, 13(5), 1-17 [10.3390/cancers13051152].

Novel cytotoxic chemotherapies in small cell lung carcinoma

Cortinovis D.
Primo
;
Bidoli P.
Secondo
;
Lavitrano M. L.;
2021

Abstract

Small cell lung cancer (SCLC) is one of the deadliest thoracic neoplasms, in part due to its fast doubling time and early metastatic spread. Historically, cytotoxic chemotherapy consisting of platinum–etoposide or anthracycline-based regimens has demonstrated a high response rate, but early chemoresistance leads to a poor prognosis in advanced SCLC. Only a fraction of patients with limited-disease can be cured by chemo-radiotherapy. Given the disappointing survival rates in advanced SCLC, new cytotoxic agents are eagerly awaited. Unfortunately, few novel chemotherapy drugs have been developed in the latest decades. This review describes the results and potential application in the clinical practice of novel chemotherapy agents for SCLC.
Articolo in rivista - Review Essay
Chemotherapy; Immunotherapy; Lurbinectedin; Small cell lung cancer;
English
8-mar-2021
2021
13
5
1
17
1152
open
Cortinovis, D., Bidoli, P., Canova, S., Colonese, F., Gemelli, M., Lavitrano, M., et al. (2021). Novel cytotoxic chemotherapies in small cell lung carcinoma. CANCERS, 13(5), 1-17 [10.3390/cancers13051152].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/318326
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