Exercise hemodynamics can differentiate heart failure with preserved ejection fraction (HFpEF) from noncardiac dyspnea. However, respiratory pressure swings may impact hemodynamic measurements, potentially leading to misdiagnosis of HFpEF. Moreover, threshold values for abnormal hemodynamic response indicative of HFpEF are not universally accepted. Thus, we sought to evaluate the impact of respiratory pressure swings on hemodynamic data interpretation as well as the concordance among 3 proposed exercise hemodynamic criteria for HFpEF: (1) end-expiratory pulmonary artery wedge pressure (PAWPexp) ≥25 mm Hg; (2) PAWPexp/cardiac output slope >2 mm Hg/L per minute; and (3) respiratory-averaged (avg) mean pulmonary artery pressure >30 mm Hg, total pulmonary resistanceavg >3 WU, PAWPavg ≥20 mm Hg.

Baratto, C., Caravita, S., Soranna, D., Faini, A., Dewachter, C., Zambon, A., et al. (2021). Current Limitations of Invasive Exercise Hemodynamics for the Diagnosis of Heart Failure With Preserved Ejection Fraction. CIRCULATION. HEART FAILURE, 14(5), 564-575 [10.1161/CIRCHEARTFAILURE.120.007555].

Current Limitations of Invasive Exercise Hemodynamics for the Diagnosis of Heart Failure With Preserved Ejection Fraction

Baratto, Claudia;Caravita, Sergio
;
Soranna, Davide;Faini, Andrea;Zambon, Antonella;Perego, Giovanni Battista;Senni, Michele;Badano, Luigi;Parati, Gianfranco;
2021

Abstract

Exercise hemodynamics can differentiate heart failure with preserved ejection fraction (HFpEF) from noncardiac dyspnea. However, respiratory pressure swings may impact hemodynamic measurements, potentially leading to misdiagnosis of HFpEF. Moreover, threshold values for abnormal hemodynamic response indicative of HFpEF are not universally accepted. Thus, we sought to evaluate the impact of respiratory pressure swings on hemodynamic data interpretation as well as the concordance among 3 proposed exercise hemodynamic criteria for HFpEF: (1) end-expiratory pulmonary artery wedge pressure (PAWPexp) ≥25 mm Hg; (2) PAWPexp/cardiac output slope >2 mm Hg/L per minute; and (3) respiratory-averaged (avg) mean pulmonary artery pressure >30 mm Hg, total pulmonary resistanceavg >3 WU, PAWPavg ≥20 mm Hg.
Si
Articolo in rivista - Articolo scientifico
Scientifica
diagnosis; exercise; heart failure; hemodynamics; hypertension;
English
564
575
12
Baratto, C., Caravita, S., Soranna, D., Faini, A., Dewachter, C., Zambon, A., et al. (2021). Current Limitations of Invasive Exercise Hemodynamics for the Diagnosis of Heart Failure With Preserved Ejection Fraction. CIRCULATION. HEART FAILURE, 14(5), 564-575 [10.1161/CIRCHEARTFAILURE.120.007555].
Baratto, C; Caravita, S; Soranna, D; Faini, A; Dewachter, C; Zambon, A; Perego, G; Bondue, A; Senni, M; Badano, L; Parati, G; Vachiéry, J
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/315254
Citazioni
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 9
Social impact