The ability to introduce controlled modifications of the genome of animals represents an important tool for biomedical and veterinary research. Among transgenic techniques, we describe here the sperm-mediated gene transfer method that is based on the spontaneous ability of sperm cells to bind and internalize exogenous DNA and to carry it to the oocyte during fertilization, producing genetically modified animals.

Lavitrano, M., Farina, L., Cerrito, M., Giovannoni, R. (2020). Sperm-Mediated Genetic Modifications. In M. Larson (a cura di), Transgenic Mouse : Methods and Protocols (pp. 125-132). Humana Press Inc. [10.1007/978-1-4939-9837-1_11].

Sperm-Mediated Genetic Modifications

Lavitrano, M
;
Farina, L;Cerrito, MG
Membro del Collaboration Group
;
Giovannoni, R
Membro del Collaboration Group
2020

Abstract

The ability to introduce controlled modifications of the genome of animals represents an important tool for biomedical and veterinary research. Among transgenic techniques, we describe here the sperm-mediated gene transfer method that is based on the spontaneous ability of sperm cells to bind and internalize exogenous DNA and to carry it to the oocyte during fertilization, producing genetically modified animals.
Capitolo o saggio
Mouse; SMGT; Spermatozoa; Transgenesis; Transgenic animals
English
Transgenic Mouse : Methods and Protocols
Larson, Melissa
2020
978-1-4939-9836-4
2066
Humana Press Inc.
125
132
Lavitrano, M., Farina, L., Cerrito, M., Giovannoni, R. (2020). Sperm-Mediated Genetic Modifications. In M. Larson (a cura di), Transgenic Mouse : Methods and Protocols (pp. 125-132). Humana Press Inc. [10.1007/978-1-4939-9837-1_11].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/296120
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