Background. Remdesivir has been associated with accelerated recovery of severe coronavirus disease 2019 (COVID-19). However, whether it is also beneficial in patients requiring mechanical ventilation is uncertain. Methods. All consecutive intensive care unit (ICU) patients requiring mechanical ventilation due to COVID-19 were enrolled. Univariate and multivariable Cox models were used to explore the possible association between in-hospital death or hospital discharge, considered competing-risk events, and baseline or treatment-related factors, including the use of remdesivir. The rate of extubation and the number of ventilator-free days were also calculated and compared between treatment groups. Results. One hundred thirteen patients requiring mechanical ventilation were observed for a median of 31 days of follow-up; 32% died, 69% were extubated, and 66% were discharged alive from the hospital. Among 33 treated with remdesivir (RDV), lower mortality (15.2% vs 38.8%) and higher rates of extubation (88% vs 60%), ventilator-free days (median [interquartile range], 11 [0–16] vs 5 [0–14.5]), and hospital discharge (85% vs 59%) were observed. Using multivariable analysis, RDV was significantly associated with hospital discharge (hazard ratio [HR], 2.25; 95% CI, 1.27–3.97; P = .005) and with a nonsignificantly lower mortality (HR, 0.73; 95% CI, 0.26–2.1; P = .560). RDV was also independently associated with extubation (HR, 2.10; 95% CI, 1.19–3.73; P = .011), which was considered a competing risk to death in the ICU in an additional survival model. Conclusions. In our cohort of mechanically ventilated patients, RDV was not associated with a significant reduction of mortality, but it was consistently associated with shorter duration of mechanical ventilation and higher probability of hospital discharge, independent of other risk factors.
Lapadula, G., Bernasconi, D., Bellani, G., Soria, A., Rona, R., Bombino, M., et al. (2020). Remdesivir use in patients requiring mechanical ventilation due to COVID-19. OPEN FORUM INFECTIOUS DISEASES, 7(11) [10.1093/ofid/ofaa481].
|Citazione:||Lapadula, G., Bernasconi, D., Bellani, G., Soria, A., Rona, R., Bombino, M., et al. (2020). Remdesivir use in patients requiring mechanical ventilation due to COVID-19. OPEN FORUM INFECTIOUS DISEASES, 7(11) [10.1093/ofid/ofaa481].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||No|
|Titolo:||Remdesivir use in patients requiring mechanical ventilation due to COVID-19|
|Autori:||Lapadula, G; Bernasconi, D; Bellani, G; Soria, A; Rona, R; Bombino, M; Avalli, L; Rondelli, E; Cortinovis, B; Colombo, E; Valsecchi, M; Migliorino, G; Bonfanti, P; Foti, G|
LAPADULA, GIUSEPPE (Corresponding)
|Data di pubblicazione:||2020|
|Rivista:||OPEN FORUM INFECTIOUS DISEASES|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1093/ofid/ofaa481|
|Appare nelle tipologie:||01 - Articolo su rivista|