Interindividual clinical variability in the course of SARS-CoV-2 infection is immense. We report that at least 101 of 987 patients with life-threatening COVID-19 pneumonia had neutralizing IgG auto-Abs against IFN-ω (13 patients), the 13 types of IFN-α (36), or both (52), at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1,227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 were men. A B cell auto-immune phenocopy of inborn errors of type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.

Bastard, P., Rosen, L., Zhang, Q., Michailidis, E., Hoffmann, H., Zhang, Y., et al. (2020). Auto-antibodies against type I IFNs in patients with life-threatening COVID-19. SCIENCE [10.1126/science.abd4585].

Auto-antibodies against type I IFNs in patients with life-threatening COVID-19

Biondi, Andrea;Bettini, Laura Rachele;D'Angio, Mariella;Bonfanti, Paolo;Pesci, Alberto
Membro del Collaboration Group
2020

Abstract

Interindividual clinical variability in the course of SARS-CoV-2 infection is immense. We report that at least 101 of 987 patients with life-threatening COVID-19 pneumonia had neutralizing IgG auto-Abs against IFN-ω (13 patients), the 13 types of IFN-α (36), or both (52), at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1,227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 were men. A B cell auto-immune phenocopy of inborn errors of type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
Articolo in rivista - Articolo scientifico
COVID19
English
Pesci, Alberto COVID-STORM Clinicians;
Bastard, P., Rosen, L., Zhang, Q., Michailidis, E., Hoffmann, H., Zhang, Y., et al. (2020). Auto-antibodies against type I IFNs in patients with life-threatening COVID-19. SCIENCE [10.1126/science.abd4585].
Bastard, P; Rosen, L; Zhang, Q; Michailidis, E; Hoffmann, H; Zhang, Y; Dorgham, K; Philippot, Q; Rosain, J; Béziat, V; Manry, J; Shaw, E; Haljasmägi, L; Peterson, P; Lorenzo, L; Bizien, L; Trouillet-Assant, S; Dobbs, K; de Jesus, A; Belot, A; Kallaste, A; Catherinot, E; Tandjaoui-Lambiotte, Y; Le Pen, J; Kerner, G; Bigio, B; Seeleuthner, Y; Yang, R; Bolze, A; Spaan, A; Delmonte, O; Abers, M; Aiuti, A; Casari, G; Lampasona, V; Piemonti, L; Ciceri, F; Bilguvar, K; Lifton, R; Vasse, M; Smadja, D; Migaud, M; Hadjadj, J; Terrier, B; Duffy, D; Quintana-Murci, L; van de Beek, D; Roussel, L; Vinh, D; Tangye, S; Haerynck, F; Dalmau, D; Martinez-Picado, J; Brodin, P; Nussenzweig, M; Boisson-Dupuis, S; Rodríguez-Gallego, C; Vogt, G; Mogensen, T; Oler, A; Gu, J; Burbelo, P; Cohen, J; Biondi, A; Bettini, L; D'Angio, M; Bonfanti, P; Rossignol, P; Mayaux, J; Rieux-Laucat, F; Husebye, E; Fusco, F; Ursini, M; Imberti, L; Sottini, A; Paghera, S; Quiros-Roldan, E; Rossi, C; Castagnoli, R; Montagna, D; Licari, A; Marseglia, G; Duval, X; Ghosn, J; Tsang, J; Goldbach-Mansky, R; Kisand, K; Lionakis, M; Puel, A; Zhang, S; Holland, S; Gorochov, G; Jouanguy, E; Rice, C; Cobat, A; Notarangelo, L; Abel, L; Su, H; Casanova, J; Pesci, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/286512
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