Interindividual clinical variability in the course of SARS-CoV-2 infection is immense. We report that at least 101 of 987 patients with life-threatening COVID-19 pneumonia had neutralizing IgG auto-Abs against IFN-ω (13 patients), the 13 types of IFN-α (36), or both (52), at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1,227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 were men. A B cell auto-immune phenocopy of inborn errors of type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.

Bastard, P., Rosen, L., Zhang, Q., Michailidis, E., Hoffmann, H., Zhang, Y., et al. (2020). Auto-antibodies against type I IFNs in patients with life-threatening COVID-19. SCIENCE, 370(6515) [10.1126/science.abd4585].

Auto-antibodies against type I IFNs in patients with life-threatening COVID-19

Biondi A.;Bettini L. R.;Bonfanti P.;Foti G.;Bellani G.;Citerio G.;Pesci A.;Valsecchi M. G.;Cazzaniga M.;
2020

Abstract

Interindividual clinical variability in the course of SARS-CoV-2 infection is immense. We report that at least 101 of 987 patients with life-threatening COVID-19 pneumonia had neutralizing IgG auto-Abs against IFN-ω (13 patients), the 13 types of IFN-α (36), or both (52), at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1,227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 were men. A B cell auto-immune phenocopy of inborn errors of type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
Articolo in rivista - Articolo scientifico
COVID19
English
24-set-2020
2020
370
6515
eabd4585
open
Bastard, P., Rosen, L., Zhang, Q., Michailidis, E., Hoffmann, H., Zhang, Y., et al. (2020). Auto-antibodies against type I IFNs in patients with life-threatening COVID-19. SCIENCE, 370(6515) [10.1126/science.abd4585].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/286512
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