BACKGROUNDDistant metastases are found in approximately 35% of patients with gastric cancer at their first clinical observation, and of these, 4%-14% involves the liver. Unfortunately, only 0.4%-2.3% of patients with metastatic gastric cancer are eligible for radical surgery. Although surgical resection for gastric cancer metastases is still debated, there have been changes in recent years, although several clinical issues remain to be defined and that must be taken into account before surgery is proposed.AIMTo analyze the clinicopathological factors related to primary gastric tumor and metastases that impact the survival of patients with liver metastatic gastric cancer.METHODSWe performed a systematic review of the literature from 2000 to 2018 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The study protocol was based on identifying studies with clearly defined purpose, eligibility criteria, methodological analysis, and patient outcome.RESULTSWe selected 47 studies pertaining to the purpose of the review, which involved a total of 2304 patients. Median survival was 7-52.3 mo, median disease-free survival was 4.7-18 mo. The 1-, 2-, 3-, and 5-year overall survival (OS) was 33%-90.1%, 10%-60%, 6%-70.4%, and 0%-40.1%, respectively. Only five papers reported the 10-year OS, which was 5.5%-31.5%. The general recurrence rate was between 55.5% and 96%, and that for hepatic recurrence was between 15% and 94%.CONCLUSIONSerous infiltration and lymph node involvement of the primary cancer indicate an unfavorable prognosis, while the presence of single metastasis or <= 3 metastases associated with a size of < 5 cm may be considered data that do not contraindicate liver resection.
Uggeri, F., Ripamonti, L., Pinotti, E., Scotti, M., Famularo, S., Garancini, M., et al. (2020). Is there a role for treatment-oriented surgery in liver metastases from gastric cancer?. WORLD JOURNAL OF CLINICAL ONCOLOGY, 11(7), 477-494.
|Citazione:||Uggeri, F., Ripamonti, L., Pinotti, E., Scotti, M., Famularo, S., Garancini, M., et al. (2020). Is there a role for treatment-oriented surgery in liver metastases from gastric cancer?. WORLD JOURNAL OF CLINICAL ONCOLOGY, 11(7), 477-494.|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||No|
|Titolo:||Is there a role for treatment-oriented surgery in liver metastases from gastric cancer?|
|Autori:||Uggeri, F; Ripamonti, L; Pinotti, E; Scotti, M; Famularo, S; Garancini, M; Gianotti, L; Braga, M; Romano, F|
UGGERI, FABIO (Corresponding)
|Data di pubblicazione:||2020|
|Rivista:||WORLD JOURNAL OF CLINICAL ONCOLOGY|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.5306/wjco.v11.i7.477|
|Appare nelle tipologie:||01 - Articolo su rivista|