We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a woman carrier of the heterozygous mutation c.568C > T p.R190W on the KCNQ1 gene. hiPSCs, obtained using four retroviruses enconding the reprogramming factors OCT4, SOX2, cMYC and KLF4, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

Mura, M., Lee, Y., Pisano, F., Ginevrino, M., Boni, M., Calabrò, F., et al. (2019). Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation. STEM CELL RESEARCH, 37 [10.1016/j.scr.2019.101437].

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation

Crotti L;
2019

Abstract

We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a woman carrier of the heterozygous mutation c.568C > T p.R190W on the KCNQ1 gene. hiPSCs, obtained using four retroviruses enconding the reprogramming factors OCT4, SOX2, cMYC and KLF4, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).
Articolo in rivista - Articolo scientifico
human induced pluripotent stem cell, long qt syndorme, cardiac potassium channel
English
2019
37
101437
open
Mura, M., Lee, Y., Pisano, F., Ginevrino, M., Boni, M., Calabrò, F., et al. (2019). Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation. STEM CELL RESEARCH, 37 [10.1016/j.scr.2019.101437].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/281501
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