Eleven previously untreated women with recurrent and/or metastatic granulosa cell tumor of the ovary were treated with cisplatin, vinblastine, and bleomycin in combination. All the six pathological complete responders but one are alive and free of disease at a median follow-up time of 14 months from the start of treatment. Of three partial responders, two died of drug-related toxicity while one, with only microscopic disease at second-look laparotomy, is alive and without evidence of disease at 34 months. Hematologic and nonhematologic toxicity were severe. These promising results require further examination of the activity and the best schedule of treatment with this combination

Colombo, N., Sessa, C., Landoni, F., Sartori, E., Pecorelli, S., Mangioni, C. (1986). Cisplatin, vinblastine, and bleomycin combination chemotherapy in metastatic granulosa cell tumor of the ovary. OBSTETRICS AND GYNECOLOGY, 67(2), 265-268 [10.1097/00006250-198602000-00020].

Cisplatin, vinblastine, and bleomycin combination chemotherapy in metastatic granulosa cell tumor of the ovary

Colombo, N;Landoni, F;Mangioni, C
1986

Abstract

Eleven previously untreated women with recurrent and/or metastatic granulosa cell tumor of the ovary were treated with cisplatin, vinblastine, and bleomycin in combination. All the six pathological complete responders but one are alive and free of disease at a median follow-up time of 14 months from the start of treatment. Of three partial responders, two died of drug-related toxicity while one, with only microscopic disease at second-look laparotomy, is alive and without evidence of disease at 34 months. Hematologic and nonhematologic toxicity were severe. These promising results require further examination of the activity and the best schedule of treatment with this combination
Articolo in rivista - Articolo scientifico
Alopecia; Bleomycin; Granulosa Cell Tumor; Middle Aged; Female; Hysterectomy; Neoplasm Staging; Humans; Nausea; Prospective Studies; Ovarian Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Child; Aged; Adult; Vinblastine; Neoplasm Metastasis; Cisplatin; Hematologic Diseases
English
265
268
4
Colombo, N., Sessa, C., Landoni, F., Sartori, E., Pecorelli, S., Mangioni, C. (1986). Cisplatin, vinblastine, and bleomycin combination chemotherapy in metastatic granulosa cell tumor of the ovary. OBSTETRICS AND GYNECOLOGY, 67(2), 265-268 [10.1097/00006250-198602000-00020].
Colombo, N; Sessa, C; Landoni, F; Sartori, E; Pecorelli, S; Mangioni, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/27513
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