Patients with Alzheimer disease (AD) produce a variety of errors on confrontation naming that indicate multiple loci of impairment along the naming process in this disease. We correlated brain hypometabolism, measured with 18fluoro-deoxy-glucose positron emission tomography, with semantic and formal errors, as well as nonwords deriving from phonological errors produced in a picture-naming test by 63 patients with AD. Findings suggest that neurodegeneration leads to: (1) phonemic errors, by interfering with phonological short-term memory, or with control over retrieval of phonological or prearticulatory representations, within the left supramarginal gyrus; (2) semantic errors, by disrupting general semantic or visual-semantic representations at the level of the left posterior middle and inferior occipitotemporal cortex, respectively; (3) formal errors, by damaging the lexical-phonological output interface in the left mid-anterior segment of middle and superior temporal gyri. This topography of semantic-lexical-phonological steps of naming is in substantial agreement with dual-stream neurocognitive models of word generation.

Isella, V., Rosazza, C., Gazzotti, M., Sala, J., Morzenti, S., Crivellaro, C., et al. (2020). A Metabolic Imaging Study of Lexical and Phonological Naming Errors in Alzheimer Disease. AMERICAN JOURNAL OF ALZHEIMER'S DISEASE AND OTHER DEMENTIAS, 35(January 1, 2020) [10.1177/1533317520922390].

A Metabolic Imaging Study of Lexical and Phonological Naming Errors in Alzheimer Disease

Isella, V
Primo
;
Morzenti, S;Crivellaro, C;Appollonio, I;Ferrarese, C;Luzzatti, C
Ultimo
2020

Abstract

Patients with Alzheimer disease (AD) produce a variety of errors on confrontation naming that indicate multiple loci of impairment along the naming process in this disease. We correlated brain hypometabolism, measured with 18fluoro-deoxy-glucose positron emission tomography, with semantic and formal errors, as well as nonwords deriving from phonological errors produced in a picture-naming test by 63 patients with AD. Findings suggest that neurodegeneration leads to: (1) phonemic errors, by interfering with phonological short-term memory, or with control over retrieval of phonological or prearticulatory representations, within the left supramarginal gyrus; (2) semantic errors, by disrupting general semantic or visual-semantic representations at the level of the left posterior middle and inferior occipitotemporal cortex, respectively; (3) formal errors, by damaging the lexical-phonological output interface in the left mid-anterior segment of middle and superior temporal gyri. This topography of semantic-lexical-phonological steps of naming is in substantial agreement with dual-stream neurocognitive models of word generation.
Articolo in rivista - Articolo scientifico
Alzheimer disease; FDG-PET; formal errors; hypometabolism; lexicon; naming impairment; phonemic errors; phonological short-term memory; phonology; semantic errors;
English
1-mag-2020
2020
35
January 1, 2020
open
Isella, V., Rosazza, C., Gazzotti, M., Sala, J., Morzenti, S., Crivellaro, C., et al. (2020). A Metabolic Imaging Study of Lexical and Phonological Naming Errors in Alzheimer Disease. AMERICAN JOURNAL OF ALZHEIMER'S DISEASE AND OTHER DEMENTIAS, 35(January 1, 2020) [10.1177/1533317520922390].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/274003
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