Luong-Gardiol et al. show that Wnt pathway activity mediated by γ-catenin is critical for BCR-ABL1 + B-ALL, in contrast to β-catenin being important in CML. B-ALL is more sensitive to partial reduction of MYC expression level than CML, and γ-catenin regulates the expression of MYC and Survivin in B-ALL.

Luong-Gardiol, N., Siddiqui, I., Pizzitola, I., Jeevan-Raj, B., Charmoy, M., Huang, Y., et al. (2019). γ-Catenin-Dependent Signals Maintain BCR-ABL1 + B Cell Acute Lymphoblastic Leukemia. CANCER CELL, 35(4), 649-663.e10 [10.1016/j.ccell.2019.03.005].

γ-Catenin-Dependent Signals Maintain BCR-ABL1 + B Cell Acute Lymphoblastic Leukemia

Pizzitola I.;Cazzaniga G.;
2019

Abstract

Luong-Gardiol et al. show that Wnt pathway activity mediated by γ-catenin is critical for BCR-ABL1 + B-ALL, in contrast to β-catenin being important in CML. B-ALL is more sensitive to partial reduction of MYC expression level than CML, and γ-catenin regulates the expression of MYC and Survivin in B-ALL.
Articolo in rivista - Articolo scientifico
B cell acute lymphoblastic leukemia (B-ALL); BCR-ABL1; BIRC5 (Survivin); chronic myeloid leukemia (CML); junction plakoglobin; MYC; β-catenin; γ-catenin; Animals; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; K562 Cells; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-myc; Survivin; beta Catenin; gamma Catenin; Wnt Signaling Pathway
English
2019
35
4
649
663.e10
open
Luong-Gardiol, N., Siddiqui, I., Pizzitola, I., Jeevan-Raj, B., Charmoy, M., Huang, Y., et al. (2019). γ-Catenin-Dependent Signals Maintain BCR-ABL1 + B Cell Acute Lymphoblastic Leukemia. CANCER CELL, 35(4), 649-663.e10 [10.1016/j.ccell.2019.03.005].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/272289
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