Honey is a food produced from honey bee widely used for the sweetening power and for its biological properties. In order to prevent the infection of the hive, different xenobiotics (antibiotics, pesticide) were frequently employed. One of these substances is the chloramphenicol, that given its chemical stability could often found in food. Chloramphenicol have several side effects in humans after their ingestion and for this reason their intake must be avoid. The aim of this study, was developed an ultrasound-assisted dispersive liquid-liquid microextraction method coupled with UHPLC MS/MS determination, for fast and accurate analysis of chloramphenicol in honey. The parameters affecting on extraction efficiency were carefully optimized using an experimental design in order to maximized the recovery reducing matrix effects. After the optimization the method was validated and successfully applied to 66 honey samples

Campone, L., Celano, R., Piccinelli, A., Pagano, I., Cicero, N., Sanzo, R., et al. (2019). Ultrasound assisted dispersive liquid-liquid microextraction for fast and accurate analysis of chloramphenicol in honey. FOOD RESEARCH INTERNATIONAL, 115, 572-579 [10.1016/j.foodres.2018.09.006].

Ultrasound assisted dispersive liquid-liquid microextraction for fast and accurate analysis of chloramphenicol in honey

Campone L.
;
2019

Abstract

Honey is a food produced from honey bee widely used for the sweetening power and for its biological properties. In order to prevent the infection of the hive, different xenobiotics (antibiotics, pesticide) were frequently employed. One of these substances is the chloramphenicol, that given its chemical stability could often found in food. Chloramphenicol have several side effects in humans after their ingestion and for this reason their intake must be avoid. The aim of this study, was developed an ultrasound-assisted dispersive liquid-liquid microextraction method coupled with UHPLC MS/MS determination, for fast and accurate analysis of chloramphenicol in honey. The parameters affecting on extraction efficiency were carefully optimized using an experimental design in order to maximized the recovery reducing matrix effects. After the optimization the method was validated and successfully applied to 66 honey samples
Articolo in rivista - Articolo scientifico
Chloramphenicol quantitative analysis; Experimental design optimisation; Honey; UA-DLLME; UHPLC MS/MS; Validation Reg. 2002/657 EC
English
2019
115
572
579
none
Campone, L., Celano, R., Piccinelli, A., Pagano, I., Cicero, N., Sanzo, R., et al. (2019). Ultrasound assisted dispersive liquid-liquid microextraction for fast and accurate analysis of chloramphenicol in honey. FOOD RESEARCH INTERNATIONAL, 115, 572-579 [10.1016/j.foodres.2018.09.006].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/267509
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