An increase in troponin I soon after high-dose chemotherapy (HDC) is a strong predictor of poor cardiological outcome in cancer patients. This finding has important clinical implications and provides a rationale for the development of prophylactic strategies for preventing cardiotoxicity. Angiotensin-converting enzyme inhibitors slow the progression of left ventricular dysfunction in different clinical settings, but their role in the prevention of cardiotoxicity has never been investigated.

Cardinale, D., Colombo, A., Sandri, M., Lamantia, G., Colombo, N., Civelli, M., et al. (2006). Prevention of high-dose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibition. CIRCULATION, 114(23), 2474-2481 [10.1161/CIRCULATIONAHA.106.635144].

Prevention of high-dose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibition

COLOMBO, NICOLETTA;
2006

Abstract

An increase in troponin I soon after high-dose chemotherapy (HDC) is a strong predictor of poor cardiological outcome in cancer patients. This finding has important clinical implications and provides a rationale for the development of prophylactic strategies for preventing cardiotoxicity. Angiotensin-converting enzyme inhibitors slow the progression of left ventricular dysfunction in different clinical settings, but their role in the prevention of cardiotoxicity has never been investigated.
Articolo in rivista - Articolo scientifico
Stroke Volume; Enalapril; Ventricular Dysfunction, Left; Male; Middle Aged; Female; Risk Factors; Dose-Response Relationship, Drug; Predictive Value of Tests; Humans; Prospective Studies; Antineoplastic Agents; Disease Progression; Angiotensin-Converting Enzyme Inhibitors; Cardiomyopathies; Troponin I; Adult; Endpoint Determination
English
5-dic-2006
114
23
2474
2481
none
Cardinale, D., Colombo, A., Sandri, M., Lamantia, G., Colombo, N., Civelli, M., et al. (2006). Prevention of high-dose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibition. CIRCULATION, 114(23), 2474-2481 [10.1161/CIRCULATIONAHA.106.635144].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/26693
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