When Delta(9)-tetrahydrocannabinol (Delta(9)-THC,15 mg/kg) was injected intraperitoneally twice a day for 6 days, tolerance to its analgesic effect appeared to be complete. Chronic exposure to Delta(9)-THC caused a significant reduction in CB1 receptor binding in all brain areas that contain this receptor. Cannabinoid receptor density was markedly reduced in the cerebellum (52%), hippocampus (40%) and globus pallidum (47%) compared to 30% in the cortex and striatum. Chronic exposure enhanced the cAMP pathway, as shown by the significant increase of cAMP levels and PKA activity in the areas with receptor down-regulation (cerebellum, striatum and cortex). We propose that the increase in cAMP cascade is part of the biochemical basis of cannabinoid tolerance
http://hdl.handle.net/10281/2626
Citazione: | Rubino, T., Viganò, D., Massi, P., Spinello, M., Zagato, E., Giagnoni, G., et al. (2000). Chronic delta-9-tetrahydrocannabinol treatment increases cAMP levels and cAMP-dependent protein kinase activity in some rat brain regions. NEUROPHARMACOLOGY, 39(7), 1331-1336. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | No |
Titolo: | Chronic delta-9-tetrahydrocannabinol treatment increases cAMP levels and cAMP-dependent protein kinase activity in some rat brain regions |
Autori: | Rubino, T; Viganò, D; Massi, P; Spinello, M; Zagato, E; Giagnoni, G; Parolaro, D |
Autori: | |
Data di pubblicazione: | 2000 |
Lingua: | English |
Rivista: | NEUROPHARMACOLOGY |
Digital Object Identifier (DOI): | 10.1016/S0028-3908(99)00196-3 |
Appare nelle tipologie: | 01 - Articolo su rivista |