Leu387Trp mutation, aroused in an imatinib-non-responsive CML patient, was selected by imatinib treatment along with other unknown factors responsible for resistance, and then it was overcome by bosutinib. These results will be useful for treating patients with this rare mutation and will advise against automatically considering a new mutation as the cause of TKI resistance.

Crespiatico, I., Bossi, E., Brioschi, F., Piazza, R., Mologni, L., Gambacorti‐passerini, C. (2020). An Imatinib–non-responsive patient with an ABL Leu387Trp mutation achieves cytogenetic and molecular response under bosutinib: Case report and biological characterization. CLINICAL CASE REPORTS, 8(1), 71-74 [10.1002/ccr3.2531].

An Imatinib–non-responsive patient with an ABL Leu387Trp mutation achieves cytogenetic and molecular response under bosutinib: Case report and biological characterization

Crespiatico, Ilaria
;
Bossi, Elisa;Piazza, Rocco;Mologni, Luca;Gambacorti‐Passerini, Carlo
2020

Abstract

Leu387Trp mutation, aroused in an imatinib-non-responsive CML patient, was selected by imatinib treatment along with other unknown factors responsible for resistance, and then it was overcome by bosutinib. These results will be useful for treating patients with this rare mutation and will advise against automatically considering a new mutation as the cause of TKI resistance.
Articolo in rivista - Articolo scientifico
chronic myeloid leukemia; genetics; hematology; resistance; TKI;
chronic myeloid leukemia; genetics; hematology; resistance; TKI
English
5-dic-2019
2020
8
1
71
74
open
Crespiatico, I., Bossi, E., Brioschi, F., Piazza, R., Mologni, L., Gambacorti‐passerini, C. (2020). An Imatinib–non-responsive patient with an ABL Leu387Trp mutation achieves cytogenetic and molecular response under bosutinib: Case report and biological characterization. CLINICAL CASE REPORTS, 8(1), 71-74 [10.1002/ccr3.2531].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/253982
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