We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes
Formicola, B., Dal Magro, R., Montefusco-Pereira, C., Lehr, C., Koch, M., Russo, L., et al. (2019). The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB. JOURNAL OF NANOBIOTECHNOLOGY, 17(1) [10.1186/s12951-019-0546-3].
The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
Formicola B.
Primo
;Dal Magro R.;Russo L.;Re F.
2019
Abstract
We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes
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