Alzheimer's disease affects millions of people worldwide and this figure is continuously increasing. Currently, there is no resolutive cure for this disorder, but a valid contribution could be provided by nanomedicine, utilizing multi-functionalized nanodevices as drug vehicles with additional features of specific brain targeting. Nanomedicine may represent also a practicable strategy for the pharmaceutical industry that moved from small MW pharmaceuticals to larger biologicals, such as antibodies and nucleotides, as the next generation of drugs, leading to the challenge of effective drug delivery. This review provides a survey on the nano-based strategies for Alzheimer's disease diagnosis and treatment, aiming at enhancing the passage of candidate pharmaceuticals across the BBB, and at supporting the evaluation of new therapeutic agents targeting this disease.

Formicola, B., Cox, A., Dal Magro, R., Masserini, M., Re, F. (2019). Nanomedicine for the treatment of Alzheimer's disease. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 15(10), 1997-2024 [10.1166/jbn.2019.2837].

Nanomedicine for the treatment of Alzheimer's disease

Formicola, B.;Cox, A.;Dal Magro, R.;Masserini, M.;Re, F
2019

Abstract

Alzheimer's disease affects millions of people worldwide and this figure is continuously increasing. Currently, there is no resolutive cure for this disorder, but a valid contribution could be provided by nanomedicine, utilizing multi-functionalized nanodevices as drug vehicles with additional features of specific brain targeting. Nanomedicine may represent also a practicable strategy for the pharmaceutical industry that moved from small MW pharmaceuticals to larger biologicals, such as antibodies and nucleotides, as the next generation of drugs, leading to the challenge of effective drug delivery. This review provides a survey on the nano-based strategies for Alzheimer's disease diagnosis and treatment, aiming at enhancing the passage of candidate pharmaceuticals across the BBB, and at supporting the evaluation of new therapeutic agents targeting this disease.
Articolo in rivista - Review Essay
Alzheimer Disease; Beta-Amyloid; Beta-Secretase; Blood-Brain Barrier; Brain; Gamma-Secretase; Nanomedicine; Nanoparticles; Blood-Brain Barrier; Drug Delivery Systems; Humans; Nanomedicine; Alzheimer Disease; Nanoparticles
English
2019
15
10
1997
2024
reserved
Formicola, B., Cox, A., Dal Magro, R., Masserini, M., Re, F. (2019). Nanomedicine for the treatment of Alzheimer's disease. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 15(10), 1997-2024 [10.1166/jbn.2019.2837].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/246545
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