DNA double-strand breaks (DSBs) are highly cytotoxic lesions that must be repaired to ensure genomic stability and avoid cell death. The cellular response to DSBs is initiated by the evolutionarily conserved Mre11-Rad50-Xrs2/NBS1 (MRX/MRN) complex that has structural and catalytic functions. Furthermore, it is responsible for DSB signaling through the activation of the checkpoint kinase Tel1/ATM. Here, we review functions and regulation of the MRX/MRN complex in DSB processing in a chromatin context, as well as its interplay with Tel1/ATM.

Casari, E., Rinaldi, C., Marsella, A., Gnugnoli, M., Colombo, C., Bonetti, D., et al. (2019). Processing of DNA double-strand breaks by the MRX complex in a chromatin context. FRONTIERS IN MOLECULAR BIOSCIENCES, 6(JUN), 43 [10.3389/fmolb.2019.00043].

Processing of DNA double-strand breaks by the MRX complex in a chromatin context

Casari, E
Co-primo
;
Rinaldi, C
Co-primo
;
Marsella, A;Gnugnoli, M;Colombo, CV;Bonetti, D;Longhese, MP
Ultimo
2019

Abstract

DNA double-strand breaks (DSBs) are highly cytotoxic lesions that must be repaired to ensure genomic stability and avoid cell death. The cellular response to DSBs is initiated by the evolutionarily conserved Mre11-Rad50-Xrs2/NBS1 (MRX/MRN) complex that has structural and catalytic functions. Furthermore, it is responsible for DSB signaling through the activation of the checkpoint kinase Tel1/ATM. Here, we review functions and regulation of the MRX/MRN complex in DSB processing in a chromatin context, as well as its interplay with Tel1/ATM.
Articolo in rivista - Review Essay
Scientifica
Double-strand break; Mre11; MRX complex; Rad50; Resection; Sae2/CtIP; Tel1/ATM; Xrs2/NBS1;
English
Casari, E., Rinaldi, C., Marsella, A., Gnugnoli, M., Colombo, C., Bonetti, D., et al. (2019). Processing of DNA double-strand breaks by the MRX complex in a chromatin context. FRONTIERS IN MOLECULAR BIOSCIENCES, 6(JUN), 43 [10.3389/fmolb.2019.00043].
Casari, E; Rinaldi, C; Marsella, A; Gnugnoli, M; Colombo, C; Bonetti, D; Longhese, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/239891
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