The cell microenvironment plays a pivotal role in mediating cell adhesion, survival, and proliferation in physiological and pathological states. The relevance of extracellular matrix (ECM) proteins in cell fate control is an important issue to take into consideration for both tissue engineering and cell biology studies. The glycosylation of ECM proteins remains, however, largely unexplored. In order to investigate the physio-pathological effects of differential ECM glycosylation, the design of affordable chemoselective methods for ECM components glycosylation is desirable. We will describe a new chemoselective glycosylation approach exploitable in aqueous media and on non-protected substrates, allowing rapid access to glyco-functionalized biomaterials.

Figuereido, I., Paiotta, A., DAL MAGRO, R., Tinelli, F., Corti, R., Re, F., et al. (2019). A new approach for glyco-functionalization of collagen-based biomaterials. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(7) [10.3390/ijms20071747].

A new approach for glyco-functionalization of collagen-based biomaterials

Alice Paiotta;Roberta Dal Magro;Francesca Tinelli;Roberta Corti;Francesca Re;Valeria Cassina;Francesco Nicotra;Laura Russo
2019

Abstract

The cell microenvironment plays a pivotal role in mediating cell adhesion, survival, and proliferation in physiological and pathological states. The relevance of extracellular matrix (ECM) proteins in cell fate control is an important issue to take into consideration for both tissue engineering and cell biology studies. The glycosylation of ECM proteins remains, however, largely unexplored. In order to investigate the physio-pathological effects of differential ECM glycosylation, the design of affordable chemoselective methods for ECM components glycosylation is desirable. We will describe a new chemoselective glycosylation approach exploitable in aqueous media and on non-protected substrates, allowing rapid access to glyco-functionalized biomaterials.
Articolo in rivista - Articolo scientifico
Biofunctionalization; Cell fate; ECM mimetics; Glyco-microenvironment; Tissue engineering;
ECM mimetics; biofunctionalization; cell fate; glyco-microenvironment; tissue engineering
English
9-apr-2019
2019
20
7
1747
open
Figuereido, I., Paiotta, A., DAL MAGRO, R., Tinelli, F., Corti, R., Re, F., et al. (2019). A new approach for glyco-functionalization of collagen-based biomaterials. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(7) [10.3390/ijms20071747].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/226962
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